Pleural Kaposi Sarcoma in Two HIV-Positive Patients

Kaposi sarcoma is a neoplasm caused by human herpes virus 8 (HHV-8) that commonly presents as subcutaneous lesions but can also involve visceral organs such as the gastrointestinal and pulmonary systems. Diagnosis is achieved through histopathological analysis of cutaneous lesions or lymph nodes. In this study, we report two patients, recently diagnosed with HIV, who were later found to have cutaneous and visceral (pleural) Kaposi sarcoma. In both cases, the patients presented with dyspnea accompanied by cutaneous lesions and bilateral pleural effusion. Unfortunately, the first patient did not survive long enough for treatment initiation. The second patient, however, demonstrated a favorable response to a treatment regimen comprising highly active antiretroviral therapy (HAART) and liposomal doxorubicin.