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Intra- and interobserver reliability of ocular surface analyzer LacryDiag®.

Eva Kos1,2, Valentina Cigić1,2, Mladen Bušić1,2

  • 1University Eye Clinic, University Hospital "Sveti Duh", Sveti Duh 64, Zagreb 10000, Croatia.

International Journal of Ophthalmology
|August 19, 2024
PubMed
Summary

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The LacryDiag ocular surface analyzer demonstrated excellent reliability for evaluating tear meniscus height (TMH) and meibography (MBG). However, interferometry showed poor interobserver reliability, indicating a need for improvement in this specific measurement.

Area of Science:

  • Ophthalmology
  • Optometry
  • Biomedical Engineering

Background:

  • Dry eye disease diagnosis relies on objective measurements of the ocular surface.
  • The LacryDiag ocular surface analyzer offers multiple assessment tools, including interferometry, tear meniscus height (TMH), and meibography (MBG).
  • Understanding the reliability of these measurements is crucial for clinical application.

Purpose of the Study:

  • To investigate the intra- and interobserver reliability of the LacryDiag ocular surface analyzer.
  • Specifically assess the reliability of interferometry, TMH measurement, and MBG using the LacryDiag device.

Main Methods:

  • Two examiners performed five consecutive measurements of interferometry, TMH, and MBG using the LacryDiag.
  • Intra- and interobserver reliability were assessed using Cohen's kappa for interferometry and intraclass correlation coefficient for TMH and MBG.
Keywords:
dry eyeinterferometrymeibographyocular surface analyzertear meniscus height

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Main Results:

  • Excellent intraobserver reliability was found for MBG (0.955-0.970).
  • Intraobserver reliability for TMH was excellent for one observer (0.863) and fair-to-good for the other (0.431).
  • Interferometry showed poor interobserver reliability (0.074) and variable intraobserver reliability (0.799 and 0.535).

Conclusions:

  • The LacryDiag is a reliable noninvasive tool for evaluating TMH and MBG.
  • Interferometry measurements require further refinement due to poor interobserver and variable intraobserver reliability.