Mantle Cell Lymphoma With Cardiac Involvement Presenting as Complete Heart Block

Area of Science:

• Cardiology
• Oncology
• Pathology

Background:

• Mantle cell lymphoma (MCL) is a rare non-Hodgkin B-cell lymphoma.
• Cardiac involvement in lymphoma is uncommon, particularly as a primary presentation.
• Intracardiac metastasis can present with diverse clinical manifestations.

Observation:

• A 50-year-old woman presented with complete heart block on electrocardiogram.
• Echocardiography identified a significant intracardiac mass with extensive cardiac involvement.
• Diagnosis of mantle cell lymphoma was confirmed through lymph node biopsy.

Findings:

• The intracardiac mass was histopathologically confirmed as mantle cell lymphoma.
• The patient received a pacemaker for heart block and underwent chemotherapy.
• Treatment resulted in notable clinical improvement and reduction of cardiac involvement.

Implications:

• This case highlights an unusual presentation of intracardiac metastasis from mantle cell lymphoma.
• It underscores the importance of considering lymphoma in the differential diagnosis of cardiac masses and conduction abnormalities.
• Early detection and multidisciplinary management are crucial for improving outcomes in rare cardiac oncological emergencies.