Related Experiment Video

Updated: Jun 16, 2025

Author Spotlight: Advancing the Detection of Low-Frequency Mutations in Cancer Tissues

Author Spotlight: Advancing the Detection of Low-Frequency Mutations in Cancer Tissues

Published on: August 23, 2024

Small cell pattern of ALK-negative anaplastic large cell lymphoma with double-hit rearrangements of DUSP22 and TP63

Yui Niiyama-Uchibori¹, Shinsuke Mizutani¹, Taku Tsukamoto¹

¹Division of Hematology and Oncology Department of Medicine Kyoto Prefectural University of Medicine Kyoto Japan.

|August 19, 2024

Abstract:

In ALK-negative anaplastic large cell lymphoma (ALCL), gene rearrangements of DUSP22 and TP63 are considered mutually exclusive. The former predicts a favorable prognosis, while the latter is generally unfavorable. We report the first case of ALK-negative ALCL in a leukemic phase with small cell pattern transformation, harboring double-hit rearrangements of the DUSP22 gene by inv(6)(p25q21) and TP63 gene by TBL1XR1-TP63 inversion. Despite the resistance to chemotherapies, the patient remained in remission with allogeneic stem cell transplantation over 20 months. Recognizing this pathologically and genetically rare condition is needed for prompt diagnosis and therapeutic decision-making in ALK-negative ALCL.

Keywords:

ALK‐negative anaplastic large cell lymphoma DUSP22 gene rearrangement TBL1XR1‐TP63 inversion TP63 gene rearrangement small cell pattern

More Related Videos

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Published on: September 20, 2016

Enhancing Tumor Content through Tumor Macrodissection

Enhancing Tumor Content through Tumor Macrodissection

Published on: February 12, 2022

Related Concept Videos

Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...

Articles linked to this work by shared authors, journal, and citation graph.

Prevalence of intestinal spirochaetosis in serrated polyposis syndrome compared with other colorectal polyp conditions: a case-control study in Japan.

BMJ open gastroenterology·2026

A case of subperiosteal clavicular chondromyxoid fibroma in a 52-year-old man: emphasis on diagnostic utility of GRM1 immunohistochemistry.

Skeletal radiology·2026

Cellular and molecular impacts of CELMoDs and IMiD on the induction of myeloid-derived suppressor cells by myeloma cells.

British journal of haematology·2026

Prediction of spread through air spaces with biopsy specimens in early-stage adenocarcinoma of the lung.

Lung cancer (Amsterdam, Netherlands)·2026

[A case of eosinophilic granulomatosis with polyangiitis presenting with characteristic endoscopic findings in the esophagus and stomach].

Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology·2026

Immune Effector Cell-Associated Hematotoxicity With Secondary Myelofibrosis Following Idecabtagene-Vicleucel for Multiple Myeloma, Comprehensively Treated With Autologous Hematopoietic Stem Cell Boosting.

EJHaem·2026

See all related articles