Cytokeratin 8 depicts nodal metastasis in head and neck squamous cell carcinoma
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View abstract on PubMed
Summary
This summary is machine-generated.Cytokeratin 8 (CK 8) expression strongly correlates with lymph node metastasis in head and neck squamous cell carcinoma (HNSCC). This finding suggests CK 8 can serve as a reliable indicator for predicting HNSCC patient prognosis.
Area Of Science
- Oncology
- Pathology
- Immunohistochemistry
Background
- Nodal involvement is critical in head and neck squamous cell carcinoma (HNSCC) prognosis.
- Current indicators for lymph node metastases and prognosis in HNSCC are insufficient.
- This study investigates cytokeratins (CKs) as potential biomarkers.
Purpose Of The Study
- To correlate the immunoexpression of cytokeratins 8, 10, and 14 with lymph node metastases in HNSCC.
- To assess the relationship between CK expression and tumor differentiation in HNSCC.
- To identify potential prognostic indicators for HNSCC.
Main Methods
- Retrospective analysis of 61 HNSCC cases with and without lymph node metastases.
- Immunohistochemical staining to assess CK 8, 10, and 14 expression.
- Statistical analysis using Pearson's Chi-square test and Spearman's correlation coefficient.
Main Results
- CK 8 expression was significantly higher in tumors with lymph node metastases compared to those without (P=0.008).
- CK 10 expression decreased with increasing tumor grade, showing a significant association with tumor differentiation (P=0.03).
- CK 14 expression did not correlate with lymph node metastasis or tumor differentiation.
Conclusions
- CK 8 immunoexpression is strongly correlated with lymph node metastasis in HNSCC.
- CK 8 shows potential as a reliable prognostic indicator for HNSCC.
- Further research may validate CK 8's role in clinical HNSCC management.
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