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Updated: Jun 16, 2025
Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor
Published on: February 16, 2018
Electrical monitoring of human-serum-albumin-templated molecularly imprinted polymer nanoparticles with high affinity
Youyuan Man1, Shoichi Nishitani2, Kazuaki Sawada3
1Department of Materials Engineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan. sakata@biofet.t.u-tokyo.ac.jp.
Abstract:
Human-serum-albumin (HSA)-templated molecularly imprinted polymer nanoparticles (nano-MIPs) were integrated with a solution-gated field-effect transistor-based biosensor. The real-time electrical analysis of nano-MIP-HSA binding showed a high affinity and specificity of nano-MIPs for HSA. Moreover, the binding behaviour was continuously visualised using a solution-gated complementary metal-oxide semiconductor array image biosensor.
