Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

16.7K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
16.7K
Experimental RNAi02:15

Experimental RNAi

6.1K
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
6.1K
Aging01:26

Aging

40
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
40
Mitochondria01:37

Mitochondria

11.7K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
11.7K
PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

3.5K
The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cervical Dystonia with Classic Sensory Tricks and Forcible Sensory Trick Showed Different Functional Connectivity Alterations: A Functional Near-Infrared Spectroscopy Study.

Journal of clinical medicine·2026
Same author

Exploring brain activity differences in functional constipation using fNIRS: a case-control study.

Journal of neuroengineering and rehabilitation·2026
Same author

Timing of surgical excision for burn wounds: A systematic evaluation and meta-analysis comparing early and delayed excision.

The Journal of international medical research·2026
Same author

Targeting DGAT1 reprograms lipid landscape and restores CD8⁺ T cell immunity in pancreatic cancer.

Nature communications·2026
Same author

Phase-Resolved Dual Control of Phenol Photodissociation at the Air-Water Interface From Structure-Resolved Statistics.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Emergence of Turing patterns in complex networks: A partial link activation approach.

Physical review. E·2026
Same journal

Utilizing Single-Cell and Transcriptomic Data to Identify Mitochondrial Pathway-Associated Prognostic Genes and Their Regulatory Mechanisms of Action in Ovarian Cancer.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same journal

Gene-Environment Interactions in Childhood Asthma: From Prenatal Exposures to Targeted Interventions.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same journal

m6A-Modified KLF11 Inhibits Macrophage Foam Cell Formation by Transcriptionally Suppressing ATP5B Expression in Atherosclerosis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same journal

Dissecting Allele-Specific Expression (ASE) in Landrace × Meishan Cross Pig Fetal-Placental Tissues: Distribution, Functional Split, and Mechanisms.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same journal

Blockade of FGFR1 Trafficking to the Cell Surface Results in the Partial Mistargeting of the Receptor to Peroxisomes.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same journal

A Myocyte-Enriched Long Non-Coding RNA NRMLncR Enhances Myogenesis in Mouse.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
See all related articles

Related Experiment Video

Updated: Jun 16, 2025

Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

33.2K

Research progress on interferon and cellular senescence.

Da Wang1, Kaixian Chen1, Zheng Wang2,3

  • 1School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, P.R. China.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|August 19, 2024
PubMed
Summary
This summary is machine-generated.

Interferon (IFN) plays a key role in cellular senescence, a major aging sign. Understanding IFN

Keywords:
body agingcellular senescenceinteractioninterferonmechanism of action

More Related Videos

Induction and Validation of Cellular Senescence in Primary Human Cells
08:18

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

16.8K
A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
13:59

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

8.1K

Related Experiment Videos

Last Updated: Jun 16, 2025

Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

33.2K
Induction and Validation of Cellular Senescence in Primary Human Cells
08:18

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

16.8K
A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
13:59

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

8.1K

Area of Science:

  • Gerontology
  • Immunology
  • Cell Biology

Background:

  • Cellular senescence is a key aging sign, involving decreased cell function.
  • Interferon (IFN) is implicated in aging processes and senescence.
  • IFN signaling pathway activation contributes to apoptosis and senescence.

Purpose of the Study:

  • To review the relationship between Interferon (IFN) and cellular senescence.
  • To explore the mechanisms by which IFN influences cellular senescence.
  • To identify potential interventions for delaying aging by targeting IFN.

Main Methods:

  • Literature review of existing research on IFN and cellular senescence.
  • Analysis of the role of IFN in the senescence-associated secretory phenotype (SASP).
  • Examination of IFN's impact on cell apoptosis and senescence pathways.

Main Results:

  • IFN is an integral component of SASP.
  • IFN signaling pathway activation is linked to increased cell apoptosis and senescence.
  • IFN influences cellular senescence through various mechanisms.

Conclusions:

  • IFN significantly impacts cellular senescence.
  • Targeting IFN pathways may offer strategies to delay aging.
  • Further research into IFN's role in senescence is warranted.