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Aquaporins

Aquaporins

Aquaporins or AQPs are a family of integral membrane proteins whose primary function is to transport water, while some called aquaglyceroporins also transport glycerol. In addition, aquaporins have also been suspected to be involved in transporting volatile substances, such as carbon dioxide and ammonia, across membranes. Such AQPs that act as gas channels are often highly expressed in cells involved in the gaseous exchange, such as red blood cells, epithelial cells, and pulmonary capillaries.

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Related Experiment Video

Updated: Jun 16, 2025

Creating Sub-50 Nm Nanofluidic Junctions in PDMS Microfluidic Chip via Self-Assembly Process of Colloidal Particles

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Self-Assembled Hydrazide-Based Nanochannels: Efficient Water Translocation and Salt Rejection.

Abhishek Mondal^1,2, Debashis Mondal^1,3, Susmita Sarkar⁴

¹Department of Chemistry, Indian Institute of Science Education and Research Pune, Dr. Homi Bhabha Road, Pashan, Pune, 411008, Maharashtra, India.

Angewandte Chemie (International Ed. in English)

|August 19, 2024

Summary

This summary is machine-generated.

Researchers developed artificial water channels (AWCs) using self-assembling hydrazides. These nanochannels mimic natural aquaporins (AQPs), selectively transporting water while blocking salts and protons.

Keywords:

Hydrazide Salt exclusion Supramolecular channel Water channel Water transport

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Area of Science:

Supramolecular Chemistry
Membrane Science
Biomimetic Materials

Background:

Nature utilizes aquaporins (AQPs) for efficient, selective water transport across membranes.
Artificial Water Channels (AWCs) aim to replicate AQP functionality synthetically.
Designing AWCs that exclude ions and protons while enabling rapid water flow remains a significant challenge.

Purpose of the Study:

To design and synthesize novel small-molecule hydrazides capable of self-assembling into functional nanochannels.
To investigate the water transport capabilities and selectivity of these self-assembled nanochannels.
To explore the potential of these AWCs as biomimetic systems for selective membrane transport.

Main Methods:

Synthesis of hydrazide derivatives (1b-1d).
Self-assembly into rosette-type nanochannel structures via hydrogen bonding and π-π stacking.
Experimental characterization of water permeability and ion/proton exclusion across lipid bilayer membranes.
Molecular Dynamics (MD) simulations to confirm channel stability and transport properties.

Main Results:

Hydrazide derivatives self-assembled into stable nanochannel assemblies.
The 1c derivative exhibited significant water permeability (3.18×10^8 molecules/sec/channel), approximately one order of magnitude lower than AQPs.
The 1c nanochannel demonstrated exclusive water passage, effectively blocking salts and protons.
MD simulations corroborated the stability and water transport mechanism within bilayer membranes.

Conclusions:

Small-molecule hydrazides can self-assemble into effective artificial water channels.
These AWCs show promise for selective water transport, mimicking natural aquaporins.
The developed hydrazide-based nanochannels offer a potential platform for applications requiring precise molecular sieving.