miRNA, New Perspective to World of Intestinal Protozoa and Toxoplasma
Faezeh Hamidi1, Niloofar Taghipour2
1Department of Laboratory Sciences and Microbiology, Faculty of Medical Sciences, Tabriz Medical Sciences, Islamic Azad University, Tabriz, Iran.
Background:
miRNAs are known as non-coding RNAs that can regulate gene expression. They are reported in many microorganisms and their host cells. Parasite infection can change or shift host miRNAs expression, which can aim at both parasite eradication and infection.
Purpose:
This study dealt with examination of miRNA expressed in intestinal protozoan, coccidia , as well as profile changes in host cell miRNA after parasitic infection and their role in protozoan clearance/ survival.
Methods:
The authors searched ISI Web of Sciences, Pubmed, Scholar, Scopus, another databases and articles published up to 2024 were included. The keywords of miRNA, intestinal protozoa, toxoplasma and some words associated with topics were used in this search.
Results:
Transfection of miRNA mimics or inhibitors can control parasitic diseases, and be introduced as a new therapeutic option in parasitology.
Conclusion:
This review can be used to provide up-to date knowledge for future research on these issues.
Insights
MicroRNAs (miRNAs) regulate gene expression and are altered during parasitic infections. Modulating these molecules offers a novel therapeutic strategy for controlling parasitic diseases.
Area of Science:
- * Molecular biology and parasitology.
- * Focus on non-coding RNAs and host-pathogen interactions.
Background:
- * MicroRNAs (miRNAs) are non-coding RNAs regulating gene expression in microorganisms and host cells.
- * Parasite infections can alter host miRNA expression, influencing parasite eradication or survival.
Purpose of the Study:
- * To examine miRNA expression in intestinal protozoa, specifically coccidia.
- * To investigate host cell miRNA profile changes post-infection.
- * To elucidate the role of miRNAs in protozoan clearance or survival.
Main Methods:
- * Comprehensive literature search of databases including Web of Science, PubMed, Scopus, and Google Scholar.
- * Inclusion of articles published up to 2024.
- * Keywords: miRNA, intestinal protozoa, coccidia, toxoplasma.
Main Results:
- * miRNA mimics and inhibitors show potential in controlling parasitic diseases.
- * miRNA-based therapies represent a new avenue in parasitology.
Conclusions:
- * This review synthesizes current knowledge on miRNAs in intestinal protozoan infections.
- * Provides a foundation for future research directions in this field.
