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Updated: Jun 16, 2025

Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging
Published on: May 24, 2021
Cardiac MRI in heart failure with preserved ejection fraction
Agostino Meduri1,2, Alessio Perazzolo1, Riccardo Marano3,4
1Department of Radiological and Hematological Sciences, Section of Radiology, Università Cattolica del Sacro Cuore, Rome, Italy.
Heart failure with preserved ejection fraction (HFpEF) presents with heart failure symptoms but normal ejection fraction. Cardiac magnetic resonance (CMR) reveals specific imaging indicators crucial for diagnosing and treating HFpEF.
Area of Science:
- Cardiology
- Medical Imaging
Background:
- Heart failure with preserved ejection fraction (HFpEF) affects patients with heart failure symptoms and preserved ejection fraction (≥50%).
- Understanding HFpEF's causes, such as myocardial diseases and diastolic dysfunction, is vital for effective management.
- Accurate diagnosis and treatment strategies depend on identifying the underlying pathophysiology of HFpEF.
Purpose of the Study:
- To discuss Cardiac Magnetic Resonance (CMR) imaging indicators specific to HFpEF.
- To explore the relationship between these CMR markers and the disease's characteristics.
- To highlight how established and emerging CMR methods can identify these indicators.
Main Methods:
- Utilizing Cardiac Magnetic Resonance (CMR) for detailed cardiac assessment.
- Measuring ventricular volumes and myocardial mass.
- Evaluating systolic and diastolic function, and analyzing tissue characteristics.
Main Results:
- CMR enables precise examination of functional and structural alterations in HFpEF.
- Specific imaging markers identified through CMR correlate with HFpEF pathophysiology.
- Both current and novel CMR techniques can detect these relevant markers.
Conclusions:
- CMR provides crucial insights into the mechanisms of HFpEF.
- Identification of specific CMR indicators aids in the diagnosis and understanding of HFpEF.
- Advanced CMR imaging holds promise for improved patient management in HFpEF.
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