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Updated: Jun 16, 2025

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
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Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway

Published on: August 23, 2024

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Research progress on the role and inhibitors of Keap1 signaling pathway in inflammation

Chao Ding1, Ying Wu2, Chaochao Zhan1

  • 1Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin 150040, China.

International Immunopharmacology
|August 19, 2024
PubMed

Insights

New Keap1 inhibitors targeting the Keap1-Nrf2 pathway offer improved specificity for treating inflammatory diseases. This approach avoids off-target effects common with traditional covalent inhibitors, paving the way for novel drug development.

Area of Science:

  • Molecular Biology
  • Pharmacology
  • Immunology

Background:

  • Inflammation is a key factor in chronic diseases.
  • The Keap1-Nrf2-ARE pathway is crucial for controlling inflammation.
  • Current Keap1 inhibitors often cause off-target effects due to covalent binding.

Purpose of the Study:

  • To review the Keap1-Nrf2-ARE pathway and its role in inflammation.
  • To summarize research on Keap1 inhibitors from 2010-2024.
  • To explore novel non-covalent Keap1 inhibitors for drug discovery.

Main Methods:

  • Literature review of Keap1-Nrf2 pathway research.
  • Analysis of anti-inflammatory drug mechanisms targeting Keap1.
  • Summary of therapeutic roles in inflammatory disease models.

Main Results:

  • The Keap1-Nrf2-ARE pathway is vital in multiple organ inflammation.
  • Non-covalent Keap1 inhibitors show promise for targeted therapy.
  • Research highlights improved specificity and Nrf2 activation.

Conclusions:

  • Targeting Keap1-Nrf2 protein-protein interactions (PPIs) is a promising therapeutic strategy.
  • Non-covalent inhibitors offer enhanced specificity and reduced side effects.
  • This review provides a comprehensive overview of Keap1-targeted anti-inflammatory drug development.
Keywords:
InflammationKeap1Keap1 inhibitorsNatural productsNrf2Oxidative stress

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