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Related Concept Videos

Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

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Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
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Drugs for Treatment of Diarrhea-Predominant IBS01:17

Drugs for Treatment of Diarrhea-Predominant IBS

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Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
153
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation01:30

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation

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Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
154
Irritable Bowel Syndrome III: Medical and Nursing Management01:30

Irritable Bowel Syndrome III: Medical and Nursing Management

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Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
188
Assessment of the Rectum and Anus01:25

Assessment of the Rectum and Anus

175
Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
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Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives01:22

Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives

189
Laxatives enhance bowel movements and alleviate constipation. They augment the stool's bulk, stimulate intestinal muscle contractions, draw water into the intestines, or soften the stool. There are five key types of laxatives: bulk laxatives, stimulant laxatives, osmotic laxatives, stool softeners, and lubricant laxatives.
Bulk-forming laxatives, such as psyllium, methylcellulose, and polycarbophil, absorb water in the intestine, increasing stool bulk and promoting bowel movement. This...
189

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Evidence-Based Clinical Guidelines for Chronic Constipation 2023.

Eikichi Ihara1,2, Noriaki Manabe1, Hidenori Ohkubo1

  • 1Guidelines Committee for Creating and Evaluating the "Evidence-Based Clinical Guidelines for Chronic Constipation 2023, The Japanese Gastroenterological Association, Bunkyo-ku, Japan.

Digestion
|August 19, 2024
PubMed
Summary
This summary is machine-generated.

The 2023 Japan Gastroenterological Association guidelines offer evidence-based strategies for chronic constipation diagnosis and treatment. They detail primary and secondary constipation management, prioritizing lifestyle changes and osmotic laxatives.

Keywords:
Chronic constipationConstipation-predominant irritable bowel syndromeDefinitionFunctional constipationGuidelines

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Area of Science:

  • Gastroenterology
  • Clinical Practice Guidelines

Background:

  • Chronic constipation is a prevalent gastrointestinal disorder affecting millions globally.
  • Existing treatment guidelines require regular updates based on emerging scientific evidence.

Purpose of the Study:

  • To present the first version of the clinical guidelines for chronic constipation (2023) from the Japan Gastroenterological Association.
  • To provide comprehensive, evidence-based recommendations for the definition, diagnosis, and management of chronic constipation.

Main Methods:

  • Systematic review of the latest scientific evidence.
  • Development of diagnostic and treatment flowcharts for chronic constipation.
  • Classification of constipation into secondary and primary forms, including functional constipation and irritable bowel syndrome with constipation-predominant subtype.

Main Results:

  • Guidelines cover definition, classification, diagnostic criteria, testing, epidemiology, pathophysiology, and treatment.
  • Treatment algorithm prioritizes differentiating secondary causes, then addressing motility disorders.
  • First-line treatments include lifestyle modification and diet, followed by osmotic laxatives, secretagogues, and ileal bile acid transporter inhibitors.

Conclusions:

  • The 2023 guidelines offer a structured approach to chronic constipation management in Japan.
  • Recommendations emphasize a stepwise treatment strategy, starting with conservative measures and progressing to pharmacotherapy.
  • These guidelines aim to optimize clinical strategies and improve patient outcomes for chronic constipation worldwide.