Spatial transcriptomic revealed intratumor heterogeneity and cancer stem cell enrichment in colorectal cancer metastasis
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View abstract on PubMed
Summary
This summary is machine-generated.Metastasis in colorectal cancer (CRC) is driven by distinct evolutionary processes and intratumoral heterogeneity. This study identifies FOXD1 as a novel marker for metastatic cancer stem cells, crucial for understanding CRC spread.
Area Of Science
- Oncology
- Genomics
- Cancer Research
Background
- Colorectal cancer (CRC) metastasis is a primary cause of patient mortality.
- Understanding CRC metastasis mechanisms is vital for clinical and fundamental research.
- CRC exhibits significant heterogeneity, impacting treatment outcomes.
Observation
- Spatial transcriptomics (ST) revealed intratumoral heterogeneity (ITH) in primary and metastatic CRC tissues.
- Metastatic tissues showed enrichment of cancer stem cells (CSCs).
- Distinct evolutionary trajectories and dedifferentiation-differentiation processes were observed during metastasis.
Findings
- FOXD1 was identified as a novel marker for metastatic CSCs.
- FOXD1 predicts patient survival, particularly in metastatic CRC.
- CD74-MIF interactions were dominant in metastatic tumor cells.
Implications
- This research provides novel insights into the cellular mechanisms of CRC liver metastasis.
- The findings lay the groundwork for developing new therapeutic strategies targeting CRC metastasis.
- Identifying FOXD1 as a CSC marker opens avenues for targeted therapies.
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