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Veillonella parvula promotes root caries development through interactions with Streptococcus mutans and Candida
Guo Li1, Yuqiu Liu2, Mengdie Zhang1
1State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Microbial Biotechnology
|August 19, 2024
Summary
Veillonella parvula significantly increases root caries by promoting harmful bacteria like Streptococcus mutans and Candida albicans. This finding offers new insights into preventing root caries in older adults.
Area of Science:
- Oral microbiology
- Dental research
- Infectious diseases
Background:
- Root caries predominantly affects older adults and is linked to dental plaque biofilm homeostasis.
- Microbial interactions within biofilms are crucial for oral microecological balance.
Purpose of the Study:
- To investigate the role of Veillonella parvula in microbial interactions and the pathogenesis of root caries.
- To understand how V. parvula influences the development and severity of root caries.
Main Methods:
- Analysis of clinical samples from patients with and without root caries.
- In vitro biofilm experiments.
- Animal studies to assess pathogenicity.
Main Results:
- Veillonella and V. parvula were abundant in the saliva of patients with root caries.
- V. parvula showed significantly increased colonization in root carious lesions.
- V. parvula colonization enhanced the abundance and virulence of Streptococcus mutans and Candida albicans, creating a more cariogenic biofilm.
Conclusions:
- V. parvula plays a critical role in the occurrence and progression of root caries.
- V. parvula contributes to enhanced biofilm anti-stress capacity and cariogenicity.
- Findings provide new insights for the etiological investigation and prevention of root caries.
