Iohexol versus iopamidol for cervical myelography: a randomised double blind study

Area of Science:

• Radiology
• Neurology
• Medical Imaging

Background:

• Cervical myelography is a diagnostic procedure to visualize the spinal cord.
• Iohexol and iopamidol are non-ionic contrast media used in myelography.
• Previous reports suggested potential differences in their efficacy and safety.

Purpose of the Study:

• To compare the safety and efficacy of iohexol and iopamidol in cervical myelography.
• To evaluate adverse reactions, radiographic quality, and EEG changes associated with each contrast agent.

Main Methods:

• A randomized, double-blind trial involving 100 consecutive patients undergoing cervical myelography.
• Procedures included lumbar puncture and direct puncture techniques.
• Electroencephalogram (EEG) examinations and adverse reaction questionnaires were administered.

Main Results:

• No significant differences were observed in side effects between iohexol and iopamidol.
• Radiographic quality of the cervical myelograms was equivalent for both agents.
• EEG sharp wave activity was comparable in both groups.

Conclusions:

• Iohexol and iopamidol are equally acceptable for all forms of cervical myelography.
• The findings contradict previous reports suggesting differential suitability.
• Both contrast agents offer equivalent safety and diagnostic performance.