Initial treatment experience obtained with the real-time predictive motion tracking radiotherapy platform Synchrony:...

This pilot study presents initial experience obtained with a real-time predictive motion tracking platform called Synchrony mounted on the Radixact radiotherapy device. Synchrony radiotherapy treatments were offered as an alternative to surgical excision for primary pulmonary carcinomas as well as in dogs in a suspected oligometastatic disease state. All dogs were treated with three fractions of 8 Gy. Six dogs with pulmonary targets were successfully treated, while we were unable to treat abdominal targets with implanted fiducials. Cranial targets showed minimal movement, while targets located adjacent to the diaphragm showed a large amplitude of movement. No acute or late clinically apparent side effects were noted in any of the dogs that received radiation therapy. A strong partial response with minimal pneumonitis was seen in follow-up imaging of the one dog where imaging was available. Synchrony motion tracking will continue to be investigated for efficacy.