Association between PPARγ polymorphisms and neurological functional disability of ischemic stroke
Summary
Peroxisome proliferator-activated receptor-γ (PPARγ) gene variations are linked to better outcomes after acute ischemic stroke (AIS). Specific PPARγ polymorphisms, rs1801282 and rs3856806, were associated with reduced disability and infarct volume in AIS patients.
Area of Science:
- Neuroscience
- Genetics
- Cardiovascular Medicine
Background:
- Peroxisome proliferator-activated receptor-γ (PPARγ) demonstrates neuroprotective effects in preclinical stroke models.
- The association between PPARγ gene polymorphisms and functional outcomes in acute ischemic stroke (AIS) patients remains largely unexplored.
Purpose of the Study:
- To investigate the relationship between functional single nucleotide polymorphisms (SNPs) in the PPARγ gene and neurological functional outcomes in a large cohort of AIS patients.
- To determine if specific PPARγ polymorphisms are associated with infarct volume and modified by inflammatory markers.
Main Methods:
- Whole-genome sequencing data from 8822 AIS patients in the Third China National Stroke Registry (CNSR-III) were analyzed.
- Two functional PPARγ SNPs, rs1801282 (C>G) and rs3856806 (C>T), were genotyped and their association with three-month neurological functional disability and infarct volume was assessed.
- Interactions with baseline IL-6 levels were examined for rs3856806.
Main Results:
- Carriers of the rs3856806 polymorphism showed significantly reduced risks for three-month neurological functional disability (OR 0.84) and lower infarct volume (OR 0.90).
- The protective effect of rs3856806 on functional disability was more pronounced in patients with lower baseline IL-6 levels (Pinteraction=0.01).
- Carriers of the rs1801282 polymorphism also exhibited a reduced risk for three-month neurological functional disability (OR 0.77).
Conclusions:
- PPARγ gene polymorphisms, specifically rs1801282 and rs3856806, are associated with improved neurological functional outcomes and reduced infarct volume in patients with AIS.
- These findings suggest that PPARγ may represent a potential therapeutic target for mitigating brain injury and improving functional recovery after stroke.
- The results highlight the importance of genetic variations in influencing stroke outcomes and underscore the potential role of PPARγ in stroke pathophysiology.
Keywords:
Peroxisome proliferator-activated receptor-γ(PPARγ)interleukin-6(IL-6)ischemic strokeneurological functional disabilitypolymorphismMore Related Videos
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