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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

493
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cancer Vaccines01:30

Cancer Vaccines

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
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  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Advanced, Recurrent, And Persistent Cervical Cancer Management: In The Era Of Immunotherapy

Advanced, recurrent, and persistent cervical cancer management: in the era of immunotherapy

Tatiana Galicia-Carmona1,2, Eder Alexandro Arango-Bravo1,2, Jaime A Coronel-Martínez1,2

  • 1Department of Clinical Research, Instituto Nacional de Cancerología (INCan), Mexico City, Mexico.

Frontiers in Oncology
|August 20, 2024

Related Experiment Videos

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
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Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

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Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
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Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025

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Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells
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Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells

Published on: February 14, 2025

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View abstract on PubMed

Summary
This summary is machine-generated.

Immunotherapy, particularly immune checkpoint inhibitors, offers new hope for cervical cancer patients. This approach is improving treatment outcomes for advanced and recurrent cervical cancer.

Area of Science:

  • Oncology
  • Immunology
  • Gynecologic Oncology

Background:

  • Cervical cancer remains a global health challenge with poor survival rates for advanced stages.
  • Current treatments for advanced cervical cancer have limited efficacy and few second-line options.
  • Understanding the tumor-immune system interaction is crucial for developing novel therapies.

Purpose of the Study:

  • To review recent advances in immunotherapy for cervical cancer.
  • To discuss current recommendations for managing metastatic, recurrent, or persistent cervical cancer with immunotherapy.
  • To highlight the role of immune checkpoint inhibitors in cervical cancer treatment.

Main Methods:

  • Review of clinical trials and current literature on immunotherapy in cervical cancer.
  • Analysis of immune checkpoint inhibitors as monotherapy and in combination regimens.
Keywords:
cervical cancercheckpoint inhibitorsimmunotherapymetastatic cervical cancer

Related Experiment Videos

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
07:29

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

11.5K
Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
09:01

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025

306
Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells
11:08

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells

Published on: February 14, 2025

722
  • Evaluation of treatment strategies for first- and second-line settings.

    • Main Results:

    • Immune checkpoint inhibitors show promising results in clinical trials for cervical cancer.
    • Combination therapies involving immune checkpoint inhibitors and chemotherapy are effective.
    • Immunotherapy is emerging as a new standard of care for advanced cervical cancer.

    Conclusions:

    • Immunotherapy, especially immune checkpoint inhibitors, is transforming cervical cancer treatment.
    • These novel therapies offer improved outcomes for patients with limited options.
    • Further research and clinical application of immunotherapy are essential for advancing cervical cancer care.
    recurrent and persistent disease