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Risk Factors for Post-Stroke Depression Following the Lifting of COVID-19 Restrictions

Shangyu Luo1, Xueqin Hu2, Yunjun Hong1

  • 1Department of Neurology, Changde Hospital, Xiangya School of Medicine, Central South University (The First People's Hospital of Changde City), Changde City, Hunan Province, People's Republic of China.

International Journal of General Medicine
|August 20, 2024
PubMed

Insights

Post-stroke depression (PSD) affects 14.15% of patients after COVID-19 restrictions eased. Key risk factors include C-reactive protein (CRP), family history of stroke, migraine, sleep duration, and thyroid-stimulating hormone (TSH).

Area of Science:

  • Neurology
  • Psychiatry
  • Public Health

Background:

  • Post-stroke depression (PSD) is a common complication following stroke.
  • Research on PSD prevalence and risk factors after the easing of COVID-19 restrictions is limited.
  • Understanding these factors is crucial for timely intervention and improved patient outcomes.

Purpose of the Study:

  • To investigate the prevalence of PSD in stroke patients after COVID-19 restrictions were lifted.
  • To identify factors associated with PSD in this population.
  • To inform clinical practice and future research directions.

Main Methods:

  • A cross-sectional study involving 947 stroke patients (cerebral hemorrhage and infarction).
  • Data collected included demographic information, Patient Health Questionnaire-9 (PHQ-9) for depression screening, C-reactive protein (CRP), homocysteine (Hcy), modified Rankin Scale (mRS), stroke characteristics, and thyroid-stimulating hormone (TSH).
  • Multiple regression analysis was used to identify independent risk factors for PSD.

Main Results:

  • The prevalence of PSD was 14.15% (PHQ-9 score ≥5).
  • Previous COVID-19 infection was not significantly correlated with PSD.
  • Independent risk factors for PSD included elevated CRP levels, family history of stroke, migraine history, shorter sleep duration, and TSH levels.

Conclusions:

  • CRP, family history of stroke, migraine, sleep duration, and TSH are significant independent risk factors for PSD.
  • These findings highlight the importance of considering these factors in the management of stroke patients post-pandemic.
  • Further research is warranted to explore the underlying mechanisms and develop targeted interventions for PSD.
Abstract

Keywords:
COVID-19depressionstrokethyroid-stimulating hormone

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