Angiomyxoma coexisting with focal nodular hyperplasia: A case report

Area of Science:

• Hepatology
• Pathology
• Surgical Oncology

Background:

• Angiomyxoma (AM) is a rare soft tissue tumor typically found in the pelvic and perineal regions.
• Extrapelvic AM, particularly in the liver, is exceptionally uncommon and prone to misdiagnosis.
• Focal Nodular Hyperplasia (FNH) is a common benign liver lesion.

Observation:

• A 56-year-old woman presented with two asymptomatic liver space-occupying lesions.
• Preoperative imaging failed to definitively diagnose the intrahepatic lesions, leading to initial misdiagnosis as other hepatic tumors.
• The coexistence of liver AM and FNH presented a diagnostic challenge due to the rarity of AM in this location.

Findings:

• Histopathological examination confirmed the presence of both angiomyxoma and focal nodular hyperplasia.
• Surgical excision was performed, and the patient experienced no recurrence or metastasis during a 1-year follow-up.
• Microscopic features were consistent with AM and FNH.

Implications:

• Accurate diagnosis of liver AM requires high clinical suspicion, especially when coexisting with more common lesions like FNH.
• Surgical resection is an effective treatment for liver AM.
• Long-term follow-up is crucial to monitor for potential recurrence of AM.