Exercise-augmented THSD7B exhibited a positive prognostic implication and tumor-suppressed functionality in...

Area of Science:

• Oncology
• Molecular Biology
• Exercise Science

Background:

• Breast cancer incidence is rising globally.
• Physical activity, especially exercise, impacts cancer prognosis and tumor biology.

Purpose of the Study:

• Investigate exercise's impact on breast cancer growth and underlying molecular mechanisms.
• Identify potential therapeutic targets modulated by exercise.

Main Methods:

• Utilized a murine breast cancer model with control and voluntary running groups.
• Conducted RNA sequencing, bioinformatics, pan-cancer, and cellular experiments.

Main Results:

• Exercise reduced tumor size and weight, upregulating THSD7B.
• THSD7B downregulation correlates with better prognosis in several cancers (PRAD, LAML, KIRC, GBM).
• THSD7B negatively impacts breast cancer cell proliferation, migration, and invasion.

Conclusions:

• Exercise modulates gene expression, offering a dual role in tumor growth.
• THSD7B is a potential prognostic marker and therapeutic target in cancer treatment.
• Further research is needed to explore exercise and THSD7B mechanisms for clinical application.