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ACUTE KIDNEY INJURY FOLLOWING ACUTE CHOLANGITIS: A RISK MULTIPLIER FOR ADVERSE OUTCOMES AND HEALTHCARE UTILIZATION
Lili Tang1, Weiwei Wan1, Jie Zhang2
1Department of Critical Care Medicine, The Fifth Affiliated Hospital (Zhuhai) of Zunyi Medical University, Zhuhai, People's Republic of China.
Shock (Augusta, Ga.)
|August 20, 2024
Summary
Acute kidney injury (AKI) frequently complicates acute cholangitis (AC), increasing mortality and healthcare costs. Identifying at-risk patients and prompt management are crucial for better outcomes in AKI following AC.
Area of Science:
- Nephrology
- Gastroenterology
- Critical Care Medicine
Background:
- Acute kidney injury (AKI) is a significant and often fatal complication of acute cholangitis (AC).
- The relationship between acute cholangitis and acute kidney injury remains incompletely understood.
- Understanding AKI incidence and risk factors in AC patients is critical for improving care.
Purpose of the Study:
- To analyze incidence trends, clinical outcomes, and healthcare resource utilization for inpatients with AKI following AC.
- To identify key risk factors associated with the development of AKI in patients with acute cholangitis.
Main Methods:
- A population-based retrospective study utilizing the National Inpatient Sample database from 2010 to 2018.
- Comparison of demographics, complications, mortality, and healthcare utilization between AC patients with and without AKI.
- Multivariate logistic regression analysis to determine AKI predictors and prognostic impact.
Main Results:
- The incidence of AKI among AC patients was 24.06%, with a generally increasing annual trend.
- AKI was linked to increased complications, invasive therapies, longer hospital stays, higher costs, and greater in-hospital mortality.
- Numerous risk factors were identified, including advanced age, comorbidities, specific hospital characteristics, and various medical conditions; female sex and certain procedures showed protective effects.
Conclusions:
- AKI is a common and serious complication of AC, associated with adverse outcomes and elevated healthcare utilization.
- Prompt identification and management of AC patients at risk for AKI are essential to mitigate negative consequences.
- Further research and clinical efforts are needed to improve the prognosis for patients experiencing AKI after AC.
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