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Determining if Admission Thromboelastography can Predict the Development of Late Resolving Multiple Organ Failure in
Ross P Smith1, Lauren K Dwyer1, Jacob C O'Dell1
1University of Kansas Medical Center, Kansas City, KS, USA.
Background:
Normal coagulation TEG values on admission negatively correlate with overall risk of multiple organ failure, but less is known about association between coagulation and late-resolving multiple organ failure (LRMOF) risk. Here, the relationship between TEG parameters and development of LRMOF was investigated.
Methods:
We conducted a retrospective assessment of patients at high postinjury multiple organ failure risk at our center. The primary outcome was LRMOF.
Results:
Analysis included 742 patients. Demographics were 76% male, mean age of 41, mean ISS of 23, 34% hypercoagulability, and 16% developed LRMOF. Patients with normal admission TEG developed LRMOF at significantly lower unadjusted rates than patients with coagulation disturbances (9 vs 16%-19%, P = 0.029); however, multivariable logistic regression demonstrated that neither coagulation profile nor individual admission TEG parameters showed association with LRMOF.
Conclusions:
In this series, we found no significant relationship between coagulation status and LRMOF development.
