Related Experiment Video
Updated: Jun 16, 2025
06:19
Evaluation of Oxidative Stress in Biological Samples Using the Thiobarbituric Acid Reactive Substances Assay
Published on: May 12, 2020
28.5K
Total Antioxidant Status and Oxidative Stress in Patients with COVID-19 Infection
Mohit Jindal1, Sarabmeet Singh Lehl2, Shivani Jaswal3
1Ex-postgraduate Student, Department of General Medicine, Government Medical College and Hospital, Chandigarh, India.
The Journal of the Association of Physicians of India
|August 20, 2024
Summary
COVID-19 severity is linked to oxidative stress and low antioxidant levels. These markers tend to recover within three months post-discharge, indicating potential for improved patient health.
Area of Science:
- Biomedical Science
- Clinical Medicine
- Pathophysiology
Background:
- Oxidative stress (OS) is implicated in the pathogenesis and severity of COVID-19.
- Investigating inflammatory markers, total antioxidant status (TAS), and malondialdehyde (MDA) is crucial for understanding disease progression.
Purpose of the Study:
- To assess the association between inflammatory markers, TAS, and MDA levels with COVID-19 severity.
- To track the trends of these markers following patient recovery.
Main Methods:
- Adult patients with moderate to severe COVID-19 were enrolled.
- Exclusion criteria included critical illness, ventilation, or septic shock.
- Levels of inflammatory markers, TAS, and MDA were measured at admission and 12 weeks post-discharge.
Main Results:
- Severe COVID-19 patients exhibited significantly lower TAS and higher MDA levels at admission compared to moderate cases.
- Admission levels of IL-6, D-dimer, and LDH were elevated in severe COVID-19.
- TAS levels increased, and MDA levels decreased 12 weeks after discharge, particularly in the severe group.
Conclusions:
- Moderate and severe COVID-19 are characterized by a state of high oxidative stress and low total antioxidant capacity.
- These biochemical markers demonstrate a trend toward recovery by three months post-discharge.
