Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ion Exchange01:17

Ion Exchange

565
Ion exchange chromatography separates charged molecules from a solution by reversibly exchanging them with mobile, or 'active', ions associated with the oppositely charged stationary phase. This method can be used to separate ions, soften and deionize water, and purify solutions. The polymers comprising the ion-exchange column are high-molecular-weight and chemically stable polymers, crosslinked to be porous and essentially insoluble. They are also functionalized with either acidic or...
565
Acidity of Carboxylic Acids01:21

Acidity of Carboxylic Acids

6.9K
Carboxylic acids are the strongest organic acids. However, their acidic strength is much less than mineral acids like HCl. Carboxylic acids ionize in water and readily lose the hydroxyl proton to form a resonance-stabilized carboxylate ion.
6.9K
Complexometric Titration: Ligands00:43

Complexometric Titration: Ligands

930
Different monodentate and polydentate ligands are used as complexing agents in complexometric titration reactions. The formation of complexes by mono- and bidentate ligands involves two or more intermediate steps, limiting their use as complexing agents. In comparison, polydentate ligands can form complexes with metal ions in a single-step process, facilitating sharper end points. This means polydentate ligands, such as amino carboxylic acid derivatives, are most commonly employed in...
930
Reactions of Carboxylic Acids: Introduction01:41

Reactions of Carboxylic Acids: Introduction

3.0K
Carboxylic acids possess an acidic –COOH functional group. The acidity can be attributed to the resonance stabilization of their conjugate base, wherein the negative charge is delocalized over both oxygen atoms.
3.0K
Amino acids03:42

Amino acids

88.6K
Amino acids are the monomers that comprise proteins. Each amino acid has the same fundamental structure, which consists of a central carbon atom, or the alpha (α) carbon, bonded to an amino group (NH2), a carboxyl group (COOH), and to a hydrogen atom. Every amino acid also has another atom or group of atoms bonded to the central atom known as the R group. There are 20 common amino acids present in proteins, each with a different R group. Variation in the amino acid sequence is responsible...
88.6K
EDTA: Chemistry and Properties01:22

EDTA: Chemistry and Properties

1.8K
Polydentate ligands are most widely used in complexometric titrations because they form more stable complexes with the metal ions than mono- or bidentate ligands due to the chelate effect. Examples of polydentate ligands are ethylenediaminetetraacetic acid (EDTA), crown ethers, and cryptands. The most important feature of optimal polydentate ligands is the ability to form 1:1 complexes in a single-step process. Amino carboxylic acid derivatives are frequently used as complexing agents. EDTA is...
1.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular signature exploration of novel Pyrazolone-derived sulfonamides against colorectal Cancer: Synthesis, biological profiling and computational modeling.

Bioorganic chemistry·2026
Same author

Free energy simulations on a biomimetic glucose receptor: understanding the selectivity of GluHUT.

Chemical science·2026
Same author

Evaluating Outcomes in Patients With Ankylosing Spondylitis Seeking Acute Care By Utilizing Elixhauser Comorbidity Index: An Analysis of Cerner Health Facts Database From 2000 to 2017.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2026
Same author

Collision risk identification and prediction considering heterogeneous braking patterns using large-scale pre-collision trajectories.

Accident; analysis and prevention·2025
Same author

The multi-pathway treatment of flavonoids as natural compounds in neurological diseases: achievements, limitations, and prospects.

Frontiers in neuroscience·2025
Same author

Nearly arbitrary terahertz metamaterials by conformal metallization on multi-photon lithography.

Optics letters·2025
Same journal

Fundamentals, Measurement and Regulation of the Conductance of Single Molecule Junctions.

Angewandte Chemie (International ed. in English)·2026
Same journal

Quantitative Photoswitching of Spin States in o-Fluoroazobenzene-Loaded Metal-Organic Frameworks.

Angewandte Chemie (International ed. in English)·2026
Same journal

Cobalt Nanoparticles Confined in Defective Carbon Matrices for Robust Intermittent CO<sub>2</sub> Methanation.

Angewandte Chemie (International ed. in English)·2026
Same journal

Copper(II/III) Redox Couple Enables C─H Methylation via a Radical Mechanism Analogous to SAM Enzymes.

Angewandte Chemie (International ed. in English)·2026
Same journal

Ring Strain Engineering of Cyclic Ethers for High-Performance Sodium Metal Batteries.

Angewandte Chemie (International ed. in English)·2026
Same journal

Bond Length as a Unified Descriptor for Stable Iodine Battery.

Angewandte Chemie (International ed. in English)·2026
See all related articles

Related Experiment Video

Updated: Jun 16, 2025

Proteomics to Identify Proteins Interacting with P2X2 Ligand-Gated Cation Channels
16:36

Proteomics to Identify Proteins Interacting with P2X2 Ligand-Gated Cation Channels

Published on: May 18, 2009

14.6K

Polyanionic Receptors for Carboxylates in Water.

Xudong Ren1, Alister J Flint1, Daniel Austin1

  • 1School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, United Kingdom.

Angewandte Chemie (International Ed. in English)
|August 20, 2024
PubMed
Summary
This summary is machine-generated.

Synthetic receptors can now bind simple carboxylate anions in water, a significant advance for biomedical applications like antibiotic mimicry. These receptors utilize charge-neutral sites, overcoming challenges posed by the aqueous biological environment.

Keywords:
Anion ReceptorsAqueous SolutionBiomimetic ReceptorsMolecular RecognitionSupramolecular Chemistry

More Related Videos

Site Directed Spin Labeling and EPR Spectroscopic Studies of Pentameric Ligand-Gated Ion Channels
11:19

Site Directed Spin Labeling and EPR Spectroscopic Studies of Pentameric Ligand-Gated Ion Channels

Published on: July 4, 2016

10.6K
Author Spotlight: Developing Parmodulins to Target Protease-Activated Receptors for Inflammation Control
07:13

Author Spotlight: Developing Parmodulins to Target Protease-Activated Receptors for Inflammation Control

Published on: May 24, 2024

442

Related Experiment Videos

Last Updated: Jun 16, 2025

Proteomics to Identify Proteins Interacting with P2X2 Ligand-Gated Cation Channels
16:36

Proteomics to Identify Proteins Interacting with P2X2 Ligand-Gated Cation Channels

Published on: May 18, 2009

14.6K
Site Directed Spin Labeling and EPR Spectroscopic Studies of Pentameric Ligand-Gated Ion Channels
11:19

Site Directed Spin Labeling and EPR Spectroscopic Studies of Pentameric Ligand-Gated Ion Channels

Published on: July 4, 2016

10.6K
Author Spotlight: Developing Parmodulins to Target Protease-Activated Receptors for Inflammation Control
07:13

Author Spotlight: Developing Parmodulins to Target Protease-Activated Receptors for Inflammation Control

Published on: May 24, 2024

442

Area of Science:

  • Supramolecular Chemistry
  • Organic Chemistry
  • Biomedical Applications

Background:

  • Carboxylate anion recognition is crucial for biomedical applications, including antibiotic design.
  • Binding polar carboxylate anions in water presents a significant challenge due to their hydrophilicity.

Purpose of the Study:

  • To develop synthetic receptors capable of recognizing simple carboxylates in aqueous solutions.
  • To investigate charge-neutral binding sites for anion recognition in water.

Main Methods:

  • Design and synthesis of tricyclic receptors with dual binding sites.
  • Incorporation of polyanionic side-chains for receptor solubilization.
  • Investigation of receptor conformation and anion binding in water.

Main Results:

  • Demonstrated the first recognition of simple carboxylates (acetate, formate) in water by synthetic receptors.
  • Utilized charge-neutral binding sites, overcoming hydrophilicity challenges.
  • Observed that polyanionic side-chains do not inhibit anion binding.

Conclusions:

  • The developed synthetic receptors show promise for selective carboxylate recognition in biological environments.
  • The tricyclic architecture, with its preorganized binding sites, mimics protein binding mechanisms.
  • Further elaboration of this architecture could lead to novel therapeutic agents.