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Projected Public Health Impact of a Universal Rotavirus Vaccination Program in France
Sharomi Oluwaseun1, Lauren Cagnan2, Ilaria Xausa3
1From the BARDS-HEDS Department, Merck & Co., Inc, Rahway, NJ.
The Pediatric Infectious Disease Journal
|August 20, 2024
Summary
Universal rotavirus vaccination in France is projected to significantly decrease rotavirus gastroenteritis (RVGE) cases and healthcare needs. High vaccination coverage could reduce RVGE cases by 84% in children under five.
Area of Science:
- Public Health
- Epidemiology
- Vaccinology
Background:
- French health authorities recommended routine rotavirus vaccination for infants in June 2022.
- The public health impact of universal rotavirus vaccination requires evaluation.
Purpose of the Study:
- To assess the public health impact of a universal rotavirus vaccination strategy in France.
- To compare vaccination scenarios against no vaccination.
Main Methods:
- A deterministic, age-structured, nonlinear dynamic transmission model was developed.
- Three vaccination coverage scenarios (high, medium, low) were analyzed.
- Outcomes included rotavirus gastroenteritis (RVGE) cases, healthcare utilization, and number needed to vaccinate.
Main Results:
- High vaccination coverage (95%) could reduce RVGE cases by 84% in children under 5 over 5 years.
- Medium (75%) and low (55%) coverage scenarios showed reductions of 72% and 47%, respectively.
- The number needed to vaccinate to prevent one RVGE case ranged from 1.86-2.04.
Conclusions:
- Universal rotavirus vaccination, particularly with high coverage, is expected to substantially reduce RVGE incidence in France.
- The strategy is anticipated to significantly decrease associated healthcare resource utilization.
