Stimuli-Responsive Covalent Organic Frameworks for Cancer Therapy
Masoud Nejabat1, Ali Samie2,3, Amir Khojastehnezhad4
1Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad 91388-13944, Iran.
ACS Applied Materials & Interfaces
|August 20, 2024
Summary
Stimuli-responsive covalent organic framework (COF) nanostructures offer advanced cancer treatment by overcoming chemotherapy limitations. These COFs enable precise drug delivery and combination therapies for enhanced anticancer efficacy.
Area of Science:
- Biomedical Engineering
- Materials Science
- Oncology
Background:
- Chemotherapy faces challenges including poor drug stability, low solubility, severe side effects, and multidrug resistance.
- Nanoparticles offer solutions as drug carriers and platforms for combined therapeutic approaches.
- Stimuli-responsive nanoparticles, triggered by tumor microenvironment or external stimuli, enhance treatment precision and selectivity.
Purpose of the Study:
- To review the potential of stimuli-responsive nanoscale covalent organic frameworks (COFs) in cancer treatment.
- To explore COFs for chemotherapy alone and in combination with other therapies.
- To highlight COFs' role in overcoming traditional chemotherapy drawbacks.
Main Methods:
- Review of recent literature on covalent organic frameworks (COFs) in nanomedicine.
- Focus on stimuli-responsive characteristics of COF nanostructures.
- Analysis of COFs' application in chemotherapy, sonodynamic, chemodynamic, photodynamic, and photothermal therapies.
Main Results:
- Covalent organic frameworks (COFs) exhibit desirable properties like large surface area, high porosity, structural stability, and biocompatibility.
- Nanoscale COFs show promise as platforms for drug delivery and combination cancer therapies.
- Stimuli-responsive COFs can be designed to target specific tumor microenvironment characteristics or respond to external triggers.
Conclusions:
- Nanoscale covalent organic frameworks (COFs) represent a promising strategy for advanced cancer therapy.
- Their stimuli-responsive nature allows for targeted drug delivery and enhanced combination treatments.
- COFs have significant potential to improve efficacy and reduce side effects compared to conventional chemotherapy.
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