Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Phases of Wound Repair01:28

Phases of Wound Repair

5.9K
Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
5.9K
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

2.7K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.7K
Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

4.0K
Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
4.0K
Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

4.8K
The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
4.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Replication-competent SIVcpz CRISPR screen identifies barriers to successful cross-species transmission.

Journal of virology·2026
Same author

TRAM-LAG1-CLN8 domain-containing protein TMEM56 regulates cell migration by changing intracellular ceramide levels.

BMC biology·2026
Same author

Multifunctional Peptide-Based Biohybrid for Targeted Reduction of Metastatic Breast Carcinoma-Associated Osteolysis.

Journal of functional biomaterials·2025
Same author

An endogenous human peptide derived from α<sub>1</sub>-antitrypsin as a novel pharmacological inhibitor of Bordetella pertussis toxin.

Naunyn-Schmiedeberg's archives of pharmacology·2025
Same author

ReaxFF-Guided Optimization of VIRIP-Based HIV-1 Entry Inhibitors.

The journal of physical chemistry. B·2025
Same author

BMP signaling promotes zebrafish heart regeneration via alleviation of replication stress.

Nature communications·2025

Related Experiment Video

Updated: Jun 16, 2025

Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.
09:06

Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.

Published on: March 25, 2020

8.6K

Wound healing: Surprising support from distant sources.

Ivonne Sehring1, Gilbert Weidinger1

  • 1Institute of Biochemistry and Molecular Biology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany.

Current Biology : CB
|August 20, 2024
PubMed
Summary
This summary is machine-generated.

Zebrafish rapidly heal skin wounds within hours, unlike mammals which take weeks. This study reveals that fin-resident epithelial cells are key to this accelerated wound closure process.

More Related Videos

Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis
06:36

Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis

Published on: August 21, 2020

12.1K
Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
07:32

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

Published on: February 17, 2021

7.0K

Related Experiment Videos

Last Updated: Jun 16, 2025

Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.
09:06

Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.

Published on: March 25, 2020

8.6K
Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis
06:36

Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis

Published on: August 21, 2020

12.1K
Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
07:32

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

Published on: February 17, 2021

7.0K

Area of Science:

  • Regenerative Medicine
  • Developmental Biology
  • Comparative Physiology

Background:

  • Cutaneous wound healing is a complex biological process crucial for tissue repair.
  • Mammalian wound healing is a slow process, often resulting in scarring.
  • Zebrafish exhibit remarkable regenerative capabilities, including rapid wound closure.

Purpose of the Study:

  • To investigate the cellular mechanisms underlying the rapid wound resurfacing in zebrafish.
  • To identify the specific cell types responsible for the accelerated healing process.

Main Methods:

  • Utilizing live imaging techniques to observe wound healing in zebrafish.
  • Employing genetic labeling to track the migration and behavior of epithelial cells during wound repair.

Main Results:

  • Zebrafish achieve complete wound coverage within hours, significantly faster than mammals.
  • Epithelial cells residing in the fins are actively mobilized to the wound site.
  • These mobilized cells contribute directly to the rapid resurfacing of the damaged skin.

Conclusions:

  • The mobilization of fin-resident epithelial cells is a critical factor in zebrafish's rapid wound healing.
  • Understanding this mechanism could offer insights into enhancing regenerative strategies in other species.