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Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

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Raptinal: a powerful tool for rapid induction of apoptotic cell death.

Amanda J Smith¹, Paul J Hergenrother²

¹Department of Chemistry, Carl R. Woese Institute for Genomic Biology, and Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.

Cell Death Discovery

|August 20, 2024

Summary

Raptinal, a novel small molecule, rapidly and reliably induces intrinsic pathway apoptosis. Its distinct mechanism and availability make it a valuable tool for biological studies and cancer research.

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Last Updated: Jun 16, 2025

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Area of Science:

Biochemistry
Cell Biology
Pharmacology

Background:

Chemical inducers of apoptosis are crucial for studying cell death pathways and treating diseases like cancer.
Existing pro-apoptotic agents have limitations in potency, universality, or speed, necessitating new compounds.

Purpose of the Study:

To introduce Raptinal as a novel small molecule inducer of apoptosis.
To highlight Raptinal's distinct mechanism and utility in biological research.

Main Methods:

Utilized Raptinal in cell culture and whole organism studies.
Investigated Raptinal's mechanism of action in inducing intrinsic pathway apoptosis.

Main Results:

Raptinal demonstrates rapid and reliable induction of intrinsic pathway apoptosis.
Its distinct mechanism complements existing cytotoxic compounds.

Conclusions:

Raptinal is a potent and versatile pro-apoptotic agent suitable for diverse biological applications.
Its rapid action and availability make it a preferred choice for apoptosis research and potential therapeutic strategies.