Related Experiment Video
Updated: Jun 16, 2025
Measurement of Heme Synthesis Levels in Mammalian Cells
Published on: July 9, 2015
High myoglobin level as an independent risk factor for death in elderly patients with critical COVID-19 infection: a
Xiaoxiao Sun1,2, Hui Zhang2, Meixian Zhang2
1Department of Critical Care Medicine, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, No. 1279, Sanmen Road, Hongkou District, Shanghai, 200434, China.
Insights
High myoglobin levels indicate a higher risk of death in critical COVID-19 patients. This finding aids in early identification of high-risk individuals, improving patient outcomes and prognosis.
Area of Science:
- Critical care medicine
- Infectious diseases
- Biomarker research
Background:
- Critical COVID-19 infection poses a significant mortality risk.
- Early identification of high-risk patients is crucial for timely intervention.
Purpose of the Study:
- To identify independent risk factors for mortality in critical COVID-19 patients.
- To establish early prognostic markers for patient survival.
Main Methods:
- Retrospective analysis of clinical data from 132 critical COVID-19 patients.
- Propensity score matching to control for confounding variables.
- Logistic regression and restricted cubic spline analysis to assess risk factors.
Main Results:
- Abnormal aspartate aminotransferase (AST), creatinine, and myoglobin were associated with increased mortality.
- Myoglobin emerged as a significant independent risk factor for death (OR=103.08, P=0.002).
- A linear relationship between myoglobin levels and mortality risk was confirmed.
Conclusions:
- Elevated myoglobin is a strong independent predictor of mortality in critical COVID-19.
- Myoglobin serves as a valuable prognostic biomarker for assessing survival in severe COVID-19 cases.
Aim:
This study aimed to discover risk factors for death in patients with critical COVID-19 infection in order to identify patients with a higher risk of death at an early stage.
Methods:
We retrospectively analyzed the clinical data of patients with critical COVID-19 infection from April 2022 to June 2022. Data were collected from the electronic medical records. Propensity matching scores were used to reduce the effect of confounding factors, such as patient baseline variables. Independent risk factors affecting patient prognosis were assessed using univariate logistic regression and multivariate logistic regression analysis. Restricted cubic spline curves were used to assess the relationship between independent and dependent variables.
Results:
The data of 132 patients with critical COVID-19 infection were included in the study. Of the 132 patients, 79 survived and 53 died. Among laboratory indicators, patients who died had higher proportions of abnormalities in procalcitonin, aspartate aminotransferase (AST), creatinine, cardiac troponin I, and myoglobin. Univariate and multivariate logistic regression analyses suggested that abnormal AST (OR = 4.98, P = 0.02), creatinine (OR = 7.93, P = 0.021), and myoglobin (OR = 103.08, P = 0.002) were independent risk factors for death. After correction for AST and creatinine, a linear relationship between myoglobin and risk of death in patients was found using restricted cubic splines.
Conclusion:
High myoglobin level is an independent risk factor for death and is therefore a prognostic marker in elderly patients with severe COVID-19 infection.
More Related Videos
08:51Intra-cardiac Side-Firing Light Catheter for Monitoring Cellular Metabolism using Transmural Absorbance Spectroscopy of Perfused Mammalian Hearts
Published on: May 12, 2019
05:58Evaluation of a Point-of-Care Testing Analyzer for Measuring Peripheral Blood Leukocytes
Published on: March 22, 2022
Related Concept Videos
01:24Hemoglobin
When all four heme groups are bound to oxygen, the resulting molecule is called oxyhemoglobin. As a result, arterial blood...
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
01:23Hypoxia
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
01:24Factors Affecting Respiration
01:27Oxygen Transport in the Blood
01:24Factors Affecting Erythropoiesis
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...