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Predictors for cause-specific and timing of deaths in patients with COVID-19: a cohort study in Taiwan

Yung-Feng Yen1,2,3,4,5, Shang-Yih Chan3,6, Yun-Ju Lai3,7,8,9

  • 1Section of Infectious Diseases, Taipei City Hospital, Heping Fuyou Branch Branch, Taipei, Taiwan.

BMC Infectious Diseases
|August 20, 2024
PubMed

Insights

Prioritizing COVID-19 vaccination and monitoring elderly and comorbid patients can reduce COVID-19 related deaths. This study identified key predictors for cause-specific and timing of deaths in hospitalized COVID-19 patients in Taiwan.

Area of Science:

  • Epidemiology
  • Infectious Diseases
  • Public Health

Background:

  • COVID-19 poses significant mortality risks, necessitating identification of predictors for death.
  • Understanding cause-specific and timing of mortality is crucial for effective patient management.

Purpose of the Study:

  • To determine predictors for cause-specific and timing of deaths in COVID-19 patients in Taiwan.
  • To identify risk factors influencing mortality outcomes in hospitalized COVID-19 cases.

Main Methods:

  • A cohort study involving laboratory-confirmed COVID-19 patients admitted to Taipei City Hospital between January 1 and July 31, 2022.
  • Follow-up until death, discharge, or August 31, 2022, with early deaths (within 2 weeks) recorded.
  • Multinomial Cox proportional hazards regression analysis used to identify predictors of cause-specific and timing of deaths.

Main Results:

  • Older age (≥65 years) significantly increased the risk of COVID-19-specific, non-COVID-19-specific, early, and late deaths.
  • Full vaccination was associated with a lower risk of COVID-19-specific and early deaths.
  • Comorbidities, such as chronic obstructive pulmonary disease, increased the risk of non-COVID-19-specific deaths.

Conclusions:

  • Prioritizing COVID-19 vaccination can reduce the risk of COVID-19-specific and early deaths.
  • Close monitoring of hospitalized patients with comorbidities is essential to mitigate non-COVID-19-specific mortality.
  • These findings support targeted interventions to improve outcomes for high-risk COVID-19 patients.
Abstract

Keywords:
COVID-19Cohort studyMortalityTaiwan

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