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Related Concept Videos

Phases of Wound Repair01:28

Phases of Wound Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...

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Dynamic optical coherence tomography for imaging acute wound healing.

Sandra Schuh1, Maximilian Berger1, Stefan Schiele2

  • 1Department of Dermatology and Allergology, University Hospital Augsburg, Augsburg, Germany.

International Wound Journal
|August 21, 2024
PubMed
Summary

Dynamic optical coherence tomography (D-OCT) visualizes blood vessel changes during acute wound healing. This imaging technique quantifies vessel growth and morphology, aiding in assessing healing progress and re-epithelialization.

Keywords:
acute woundsangiogenesisoptical coherence tomographyre‐epithelializationwound healing

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Area of Science:

  • Biomedical Engineering
  • Medical Imaging
  • Wound Healing Research

Background:

  • Assessing acute wound healing traditionally relies on visual inspection and indirect measures.
  • Understanding the microvascular changes is crucial for effective wound management and predicting healing outcomes.

Purpose of the Study:

  • To investigate acute wound healing processes using dynamic optical coherence tomography (D-OCT).
  • To analyze changes in blood vessel characteristics within wound beds and surrounding tissues during the healing period.

Main Methods:

  • D-OCT was employed to measure vascular parameters (orientation, density, diameter, morphology, pattern) in 23 split skin graft donor sites from 22 patients.
  • Measurements were taken at six time points, from surgery up to 4 weeks post-operation, including wound edges, wound bed, and healthy skin.
  • Analysis included horizontal, vertical, and 3D imaging to assess angiogenesis and vascular remodeling.

Main Results:

  • Significant differences in vessel morphology (blobs, serpiginous) were observed between normal and wounded skin at 300 μm depth.
  • Wounded skin exhibited more vertically oriented vessels, increased branching, density, and diameter compared to healthy skin.
  • 3D imaging revealed increased angiogenesis towards the wound center, with the highest vessel density at the wound-healthy skin interface. Vessel density fluctuated during healing, peaking initially, then decreasing before increasing by 4 weeks.

Conclusions:

  • D-OCT provides a non-invasive method to visualize and quantify microvascular changes during acute wound healing.
  • The study demonstrates D-OCT's capability in evaluating angiogenesis and vascular remodeling, complementing assessments of re-epithelialization.
  • This technology can enhance the understanding and management of acute wounds by providing detailed insights into vascular dynamics.