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Response Surface Methodology

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Removal of Amoxicillin From Wastewater Onto Activated Carbon: Optimization of Analytical Parameters by Response

Moussa Abbas¹, Mohamed Trari²

¹Laboratory of Applied Chemistry and Materials (LabCAM), University of M'hamed Bougara of Boumerdes, Boumerdes, Algeria.

Dose-Response : a Publication of International Hormesis Society

|August 21, 2024

Summary

This study optimized activated carbon for removing Amoxicillin from water, achieving 90% efficiency. The best conditions involved specific pH, temperature, and carbon dose, indicating chemisorption is key.

Keywords:

activated carbon adsorption amoxicillin isotherm modeling optimization

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Area of Science:

Environmental Chemistry
Water Treatment Technologies
Adsorption Science

Background:

Antibiotics in aquatic environments pose risks to organisms.
Effective removal of pharmaceuticals like Amoxicillin is crucial for environmental protection.

Purpose of the Study:

To optimize the removal of Amoxicillin using activated carbon.
To characterize activated carbon and determine optimal adsorption conditions.

Main Methods:

Activated carbon characterization (FT-IR, BET, SEM).
Optimization using Response Surface Methodology (RSM) and Box-Behnken Design (BBD).
Adsorption modeling (Langmuir, Freundlich, etc.) and kinetic analysis (pseudo-second order).

Main Results:

Optimal conditions: 0.124 g AC dose, pH 5.03, 45°C, yielding 89.999% Amoxicillin removal.
Langmuir model best described equilibrium data (qmax = 142.85 mg/g).
Adsorption followed pseudo-second order kinetics, indicating chemisorption dominance.

Conclusions:

Activated carbon is effective for Amoxicillin removal.
Optimization using RSM and BBD successfully identified key parameters (pH > Temperature > Dose).
Chemisorption is the primary mechanism for Amoxicillin adsorption onto activated carbon.