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Related Concept Videos

Skeletal Muscle Relaxants: Therapeutic Uses01:31

Skeletal Muscle Relaxants: Therapeutic Uses

477
Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx...
477
Local Anesthetics: Clinical Application as Spinal Anesthesia01:11

Local Anesthetics: Clinical Application as Spinal Anesthesia

594
Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
594

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Related Experiment Video

Updated: Jun 16, 2025

Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation
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INTRATHECAL BACLOFEN FOR NEUROFIBROMATOSIS RELATED SPINAL CORD INJURY WITH SPASTICITY - A CASE REPORT.

Carl O'Brien1, Jacqui Stowe1, Michael O'Connor2

  • 1National Rehabilitation Hospital, Rochestown Avenue, Dun Laoghaire Co.

Journal of Rehabilitation Medicine. Clinical Communications
|August 21, 2024
PubMed
Summary

Intrathecal baclofen effectively managed severe spasticity in a neurofibromatosis-1 patient with spinal cord injury. This treatment improved mobility and daily living independence, enhancing quality of life.

Keywords:
intrathecal baclofenneurofibromatosis 1spasticityspinal cord injury

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Area of Science:

  • Neuroscience
  • Neurosurgery
  • Rehabilitation Medicine

Background:

  • Neurofibromatosis-1 (NF1) can lead to spinal tumors causing neurological deficits.
  • Spinal cord injury (SCI) in NF1 patients presents complex management challenges, often involving severe spasticity.

Observation:

  • A 35-year-old male with spinal NF1 developed an incomplete C3 ASIA C spinal cord injury due to cervical neurofibromas.
  • Despite decompressive surgery, the patient experienced significant lower limb weakness and severe spasticity, requiring substantial assistance.

Findings:

  • A trial of intrathecal baclofen was successful in managing the patient's severe spasticity.
  • Following pump implantation and progressive rehabilitation, the patient's Modified Ashworth Scale (MAS) score improved to 1-2/4.
  • The patient achieved independent transfers and independence in most activities of daily living.

Implications:

  • Intrathecal baclofen represents a novel and effective treatment for severe spasticity in spinal NF1 patients with SCI.
  • This therapeutic approach can significantly improve functional independence and quality of life in patients with complex neurological conditions.
  • Early consideration of intrathecal baclofen may be beneficial for managing spasticity post-SCI in NF1.