Association Between Different Metabolic Obesity Phenotypes and Erosive Esophagitis: A Retrospective Study

Area of Science:

• Gastroenterology
• Metabolic Health
• Obesity Research

Background:

• Obesity is linked to increased risks of erosive esophagitis (EE).
• Metabolic abnormalities are key factors in EE development.
• Understanding metabolic obesity phenotypes is crucial for assessing EE risk.

Purpose of the Study:

• To evaluate the association between distinct metabolic obesity phenotypes and the risk of developing EE.
• To investigate sex and age-specific risks related to metabolic obesity and EE.

Main Methods:

• Retrospective study of 11,599 subjects undergoing upper gastrointestinal endoscopy.
• Classification into four groups: metabolically healthy non-obesity (MHNO), metabolically healthy obesity (MHO), metabolically unhealthy non-obesity (MUNO), and metabolically unhealthy obesity (MUO).
• Multivariate logistic regression analysis to determine the relationship between phenotypes and EE risk.

Main Results:

• MUNO, MHO, and MUO groups showed higher EE risks than the MHNO group.
• The MUO group had the highest EE risk (ORs: 5.473 for males, 7.566 for females).
• EE risk increased with the proportion of metabolic risk factors; obesity showed a stronger influence than metabolic disorders.

Conclusions:

• Both metabolic disorders and obesity elevate EE risk, with obesity being a more significant factor.
• Clinical strategies should target both obesity and metabolic abnormalities to reduce EE incidence.
• Identifying specific metabolic obesity phenotypes can inform targeted prevention and treatment approaches for EE.