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Updated: Jun 16, 2025

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
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SNORA5A regulates tumor-associated macrophage M1/M2 phenotypes via TRAF3IP3 in breast cancer

Yiqi Zhang1, Ang Zheng2, Yue Shi1

  • 1Department of Surgery, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas
|August 21, 2024
PubMed

Insights

Small nucleolar RNA SNORA5A is down-regulated in breast cancer, impacting tumor-associated macrophage phenotypes and patient prognosis. Its regulation of macrophages via TRAF3IP3 suggests potential as a therapeutic target.

Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Background:

  • Small nucleolar RNAs (snoRNAs) show promise for breast cancer therapy.
  • The specific role of SNORA5A in breast cancer remains largely unexplored.

Purpose of the Study:

  • To investigate the function and prognostic value of SNORA5A in breast cancer.
  • To elucidate the relationship between SNORA5A, tumor-associated macrophages, and potential downstream targets.

Main Methods:

  • Analysis of The Cancer Genome Atlas (TCGA) transcription matrix and clinical data using R software.
  • Validation of findings in clinical breast cancer tissue samples.
  • Bioinformatic analysis to identify downstream molecules and related functions.

Main Results:

  • SNORA5A was significantly downregulated in breast cancer tissues.
  • High SNORA5A expression correlated with favorable prognosis and modulated M1/M2 macrophage balance.
  • TRAF3IP3 was identified as a downstream molecule regulated by SNORA5A, influencing macrophage polarization.

Conclusions:

  • SNORA5A plays a crucial role in regulating macrophage phenotypes in breast cancer, potentially through TRAF3IP3.
  • SNORA5A represents a promising prognostic biomarker and therapeutic target for breast cancer.

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