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Related Concept Videos

Lysosomes01:31

Lysosomes

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Lysosomes are membrane-enclosed spherical sacs derived from the Golgi apparatus. The most important function of the lysosome is degrading macromolecules and biological polymers that are released during membrane trafficking events such as the secretory, endocytic, autophagic, and phagocytic pathways. The degradation is carried out by several hydrolytic enzymes active in an acidic environment of the lysosomal lumen. These acid hydrolases are involved in cellular processes such as cell signaling,...
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Lysosomal Hydrolases01:22

Lysosomal Hydrolases

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Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
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Delivery Pathways to the Lysosome01:36

Delivery Pathways to the Lysosome

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Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
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Autophagic Cell Death01:18

Autophagic Cell Death

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Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
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Autophagy01:27

Autophagy

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Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
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Updated: Jun 16, 2025

Characterization of Neuronal Lysosome Interactome with Proximity Labeling Proteomics
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Characterization of Neuronal Lysosome Interactome with Proximity Labeling Proteomics

Published on: June 23, 2022

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Switching on lysosomes.

Deepak Adhikari1, John Carroll1

  • 1Development and Stem Cell Program and the Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Australia.

Elife
|August 21, 2024
PubMed
Summary
This summary is machine-generated.

In unfertilized eggs, large endolysosomal structures keep lysosomes dormant. After fertilization, these structures activate lysosomes for essential clean-up during the egg-to-embryo transition.

Keywords:
ELYSAcell biologydevelopmental biologyembryoendosomefertilizationlysosomemouseoocyte

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Area of Science:

  • Cell Biology
  • Developmental Biology
  • Reproductive Science

Background:

  • Unfertilized eggs contain large endolysosomal structures.
  • Lysosomes are typically dormant in the unfertilized egg state.

Discussion:

  • These structures regulate lysosomal activity, preventing premature function.
  • The transition from egg to embryo triggers a shift in lysosomal behavior.

Key Insights:

  • Formation of large endolysosomal structures is crucial for maintaining lysosomal dormancy.
  • Lysosomes become active for cellular clean-up post-fertilization.

Outlook:

  • Understanding this mechanism can provide insights into early embryonic development.
  • Further research may explore the role of endolysosomal dynamics in reproductive health.