Related Experiment Video

Updated: Jun 16, 2025

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

355

Association of partial infections with the risk of psoriasis: A two-sample Mendelian randomization study

Minghui Lu1, Changyong Gao1, Runtian Zhang1

  • 1Dongzhimen Hospital, Beijing University of Traditional Chinese Medicine, Beijing, China.

Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [And] International Society for Digital Imaging of Skin (ISDIS) [And] International Society for Skin Imaging (ISSI)
|August 21, 2024
PubMed
Abstract

Insights

Epstein-Barr virus (EBV) infection is causally linked to psoriasis, potentially increasing disease risk and severity. Preventing EBV infection may help manage psoriasis symptoms and prevent recurrence.

Area of Science:

  • Immunology
  • Dermatology
  • Genetics

Background:

  • Psoriasis is a chronic inflammatory skin disease with erythema and scaly lesions.
  • Infection is implicated in disease pathogenesis, but causal links remain unclear.
  • Previous studies suggest psoriasis impacts infection, but causality is not fully established.

Purpose of the Study:

  • To investigate the causal relationship between infections and psoriasis.
  • To clarify the role of specific pathogens in psoriasis development.

Main Methods:

  • Utilized GWAS catalog and UK Biobank data for 13 pathogens and psoriasis phenotype.
  • Employed Mendelian Randomization (MR) with Inverse Variance Weighted (IVW), Weighted Median (WME), and MR-Egger regression.
  • Analyzed 46 species of Single Nucleotide Polymorphism (SNP) data.

Main Results:

  • A causal relationship was identified between anti-Epstein-Barr virus (EBV) antibody and psoriasis.
  • The association showed a positive correlation (OR: 1.003, 95% CI: 1.001–1.006, P = 0.046).

Conclusions:

  • EBV infection is causally linked to psoriasis, increasing risk and severity.
  • Preventing EBV infection is crucial for managing psoriasis patients.
  • Findings offer new perspectives for immunological research into psoriasis.
Keywords:
Epstein Barr virusMendelian randomizationimmune responsepsoriasis

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