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Related Concept Videos

Urinary Tract Infection I: Introduction01:26

Urinary Tract Infection I: Introduction

Urinary tract infections (UTIs) impact various parts of the urinary system, including the kidneys, ureters, bladder, and urethra. These infections are generally bacterial, with Escherichia coli being the most common causative agent, often originating from the gastrointestinal tract. However, other bacteria, such as Staphylococcus saprophyticus, Klebsiella pneumoniae, and Proteus mirabilis, are also known to cause UTIs. The type, location, and underlying complexity of the UTI guide both...
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care01:30

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
Urinary Tract Infection IV: Nursing Management01:17

Urinary Tract Infection IV: Nursing Management

In managing urinary tract infections (UTIs) in nursing, a comprehensive assessment is essential. Begin by gathering subjective data, such as the patient’s complaints of dysuria (painful urination), urinary frequency, urgency, suprapubic pain, and any lower abdominal discomfort. This information can be complemented by questions regarding previous UTIs, sexual activity, and personal hygiene practices, which can provide insight into risk factors. Objective assessment should focus on signs like...
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
Urine Studies II: Urine Culture and Sensitivity Test01:26

Urine Studies II: Urine Culture and Sensitivity Test

A urine culture and sensitivity test is a diagnostic procedure used to identify urinary tract bacterial infections and determine the most effective antibiotics for treatment. This test is generally preferred when a patient shows manifestations of a urinary tract infection, such as frequent or painful urination, cloudy or foul-smelling urine, or lower abdominal pain.Purpose of the TestThe primary goals of a urine culture and sensitivity test are to:Determine the specific bacteria causing the...

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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Linezolid in enterococcal urinary tract infection: a multicentre study.

Léa Malinowski1, Souheil Zayet2, Myriam Chiaruzzi3

  • 1Department of infectious and tropical diseases, Besançon University Hospital, Besançon, F-25000, France.

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
|August 21, 2024
PubMed
Summary

Linezolid demonstrates good efficacy and safety for treating enterococcal urinary tract infections (e-UTI). This study found a low treatment failure rate and minimal adverse events in patients receiving linezolid for e-UTI.

Keywords:
Enterococcus faecalisEnterococcus faeciumEnterococcusLinezolidUrinary tract infection

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Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Urology

Background:

  • Enterococcal urinary tract infections (e-UTI) are challenging to treat.
  • Limited data exist on linezolid's effectiveness for e-UTI.
  • Understanding treatment outcomes is crucial for patient management.

Purpose of the Study:

  • To characterize patients with e-UTI treated with linezolid.
  • To evaluate the efficacy of linezolid in treating e-UTI.
  • To assess the safety and tolerance of linezolid for e-UTI.

Main Methods:

  • Observational, multicenter, retrospective study in 5 French hospitals.
  • Included patients (≥18 years) with confirmed enterococcal UTI and linezolid treatment >48 hours.
  • Primary outcome was clinical failure; data collected on patient characteristics, treatment, and outcomes.

Main Results:

  • Eighty-one patients (median age 73) were included; E. faecium (80%) and E. faecalis (32%) were common pathogens.
  • No vancomycin-resistant enterococci were identified.
  • Linezolid treatment (median 13 days) showed a low clinical failure rate (2.5%) and few, non-serious adverse events.

Conclusions:

  • Linezolid is an effective and safe treatment option for enterococcal UTIs.
  • The study provides valuable real-world evidence supporting linezolid use in this indication.
  • Further research may explore optimal duration and specific patient subgroups.