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Associations between insomnia and cardiovascular diseases: a meta-review and meta-analysis of observational and

Xuejiao Zhang1, Yujing Sun1, Shuo Ye1

  • 1Department of Cardiology, Heart Center, The First Affiliated Hospital of Xinxiang Medical University, Weihui, China.

Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine
|August 21, 2024
PubMed

Insights

This study found strong evidence that insomnia is a risk factor for cardiovascular diseases (CVDs). Treating insomnia may help prevent heart conditions like heart attack and hypertension.

Area of Science:

  • Cardiology
  • Sleep Medicine
  • Genetics

Background:

  • Observational studies suggest a link between insomnia and cardiovascular diseases (CVDs).
  • The causal relationship between insomnia and CVDs requires further investigation.
  • This study aims to clarify the causal mechanisms by combining meta-review and meta-analysis.

Purpose of the Study:

  • To investigate the potential causal associations between insomnia and various cardiovascular diseases.
  • To synthesize evidence from both observational and Mendelian randomization studies.
  • To identify insomnia as a modifiable risk factor for CVD prevention.

Main Methods:

  • A systematic meta-review and meta-analysis of observational and Mendelian randomization studies.
  • Searched PubMed, Web of Science, and Embase databases for relevant English-language articles up to July 2023.
  • Two independent reviewers screened studies to minimize bias and ensure data quality.

Main Results:

  • Observational studies indicated insomnia is an independent risk factor for atrial fibrillation, myocardial infarction, and hypertension.
  • Mendelian randomization studies revealed potential causal links between insomnia and coronary artery disease, atrial fibrillation, heart failure, hypertension, large artery stroke, any ischemic stroke, and primary intracranial hemorrhage.
  • No causal association was found between insomnia and cardioembolic or small vessel stroke.

Conclusions:

  • The study provides robust evidence supporting a causal association between insomnia and increased cardiovascular disease risk.
  • Treating insomnia emerges as a potential therapeutic strategy for the prevention of cardiovascular diseases.
  • Further research into sleep-disordered breathing and its cardiovascular implications is warranted.
Abstract

Keywords:
Mendelian randomizationcardiovascularinsomniameta-reviewobservational study

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