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Updated: Jun 15, 2025

Author Spotlight: Experimental Approaches for the Synthesis of Low-Valent Metal-Organic Frameworks from Multitopic Phosphine Linkers
Published on: May 12, 2023
A Modular Three-Component Approach for Site-selective Tandem Arene Thiophosphorylation
Ziyu Gan1, Shuyang Liu1, Jiajin Chen1
1State Key Laboratory of Fine Chemicals, School of Chemistry, Dalian University of Technology, Dalian 116024, China.
Abstract:
Thiophosphates serve as pivotal reagents within the realms of both organic and inorganic synthesis, with their most notable applications observed in agricultural chemistry. This manuscript delineates a modular three-component synthetic strategy for site-selective arene C-H thiophosphorylation with thianthrenium salt, 1,4-diazabicyclo[2.2.2]octane-sulfur dioxide (DABSO), and diarylphosphine oxides as substrates. This approach facilitates the metal-free and green synthesis of a diverse spectrum of S-aryl phosphorothioates through C-H functionalization and late-stage modification showcasing practicality and broad applicability.
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