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Related Experiment Videos

Mitochondrial integrity and maltose utilization in yeast.

N A Khan1

  • 1Department of Biology, Brooklyn College of the City, University of New York 11210.

Current Genetics
|January 1, 1985
PubMed
Summary
This summary is machine-generated.

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Yeast Saccharomyces cerevisiae utilizes maltose via two pathways: an oxidative route requiring mitochondria and a fermentative route independent of mitochondrial function. Mutants highlight these distinct maltose utilization mechanisms.

Area of Science:

  • * Yeast genetics and molecular biology
  • * Cellular respiration and fermentation pathways

Background:

  • * Specific strains of Saccharomyces cerevisiae exhibit a unique dependency on functional mitochondria for maltose utilization.
  • * These strains, while capable of growth on maltose with mitochondria, show poor anaerobic fermentation of maltose.

Purpose of the Study:

  • * To investigate the mechanisms underlying maltose utilization in Saccharomyces cerevisiae.
  • * To explore the relationship between mitochondrial function and maltose metabolism.
  • * To identify distinct pathways for maltose assimilation in yeast.

Main Methods:

  • * Isolation and characterization of yeast strains (Saccharomyces cerevisiae) with specific maltose utilization phenotypes.
  • * Generation and analysis of glycerol-negative mitochondrial mutants.

Related Experiment Videos

  • * Phenotypic analysis of revertant strains on various growth media (maltose agar, glycerol).

    • Main Results:

    • * Certain yeast strains require functional mitochondria for maltose utilization, displaying poor anaerobic fermentation.
    • * Glycerol-negative mutants derived from these strains also lose the ability to utilize maltose.
    • * Reversion to glycerol utilization in mutants was accompanied by a restoration of maltose utilization.

    Conclusions:

    • * Two distinct mechanisms for maltose utilization exist in yeast: an oxidative pathway dependent on mitochondria and a fermentative pathway independent of mitochondrial integrity.
    • * Mitochondrial function is crucial for the oxidative maltose assimilation pathway.
    • * The findings suggest a complex interplay between respiration and fermentation in yeast carbohydrate metabolism.