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Related Experiment Video

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Reducing Distress from Auditory Verbal Hallucinations: A Multicenter, Parallel, Single-Blind, Randomized Controlled

Tania Marie Lincoln1, Björn Schlier1,2, Rebecca Müller1

  • 1Clinical Psychology and Psychotherapy, Institute of Psychology, Faculty of Psychology and Human Movement Science, Universität Hamburg, Hamburg, Germany.

Psychotherapy and Psychosomatics
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PubMed
Summary

Relating Therapy (RT) added to treatment as usual (TAU) is a feasible and safe intervention for reducing distress from auditory verbal hallucinations (AVHs). This study supports further testing of RT

Keywords:
HallucinationsPsychosisPsychotherapyRandomized-controlled trialRelating

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Area of Science:

  • Psychiatry
  • Clinical Psychology

Background:

  • Auditory verbal hallucinations (AVHs) cause significant distress for individuals with schizophrenia-spectrum disorders.
  • Current treatments often focus on symptom reduction, but distress is linked to the individual's relationship with AVHs.

Purpose of the Study:

  • To assess the feasibility of a randomized controlled trial (RCT) for "Relating Therapy" (RT) combined with treatment as usual (TAU).
  • To determine if RT + TAU is superior to TAU alone in reducing distress associated with AVHs.

Main Methods:

  • A multicenter, single-blind, randomized controlled feasibility trial involving 177 participants with persistent, distressing AVHs and schizophrenia-spectrum disorders.
  • Participants received either RT + TAU or TAU alone, with assessments at baseline, 5, and 9 months.
  • Feasibility outcomes included recruitment, retention, safety, and therapist adherence, with AVH distress as the primary endpoint.

Main Results:

  • The study demonstrated excellent feasibility with 87% retention at 9 months and high therapist adherence (98%).
  • No serious adverse reactions were reported, indicating a favorable safety profile.
  • RT + TAU showed non-significant trends toward reduced AVH distress compared to TAU alone.

Conclusions:

  • A randomized controlled trial investigating Relating Therapy is feasible, safe, and well-accepted by participants.
  • These findings provide a strong foundation for conducting a definitive trial to confirm the efficacy of RT in reducing AVH distress.