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Correlations of Long Noncoding RNA HNF4A-AS1 Alternative Transcripts with Liver Diseases and Drug Metabolism

Jing Jin1, Le Tra Giang Nguyen1, Andrew Wassef1

  • 1Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut (J.J., L.T.G.N., T.P.R., X.-B.Z.); Departments of Pharmaceutics (A.W.) and Pharmacology and Toxicology (G.L.G.), Ernst Mario School of Pharmacy, and Center of Excellence for Pharmaceutical Translational Research and Education (A.W., R.S.), Rutgers University, Piscataway, New Jersey; Center of Excellence for Metabolic and Bariatric Surgery, Robert Wood Johnson Barnabas University Hospital, New Brunswick, New Jersey (A.W.); and Department of General Surgery, University of Kansas Medical Center, Kansas City, Kansas (T.M.S.).

Drug Metabolism and Disposition: the Biological Fate of Chemicals
|August 21, 2024
PubMed
Summary

Hepatocyte nuclear factor 4 alpha antisense 1 (HNF4A-AS1) long noncoding RNA has multiple transcripts. This study identifies six HNF4A-AS1 transcripts and analyzes their roles in liver diseases and drug metabolism, aiding targeted therapies.

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