Related Experiment Video
Updated: Jun 15, 2025

Anesthesia and Intubation of Preadolescent Mouse Pups for Cardiothoracic Surgery
Published on: June 2, 2022
Duration of perioperative antibiotic prophylaxis in neonatal surgery: Less is more
Spencer Wilhelm1, Michael Tolkacz1, Lior Kopel2
1Department of Surgery, Corewell Health William Beaumont University Hospital, Royal Oak, MI, 48073, USA.
Background:
The ideal duration of neonatal antibiotic prophylaxis is not determined with wide variance in practice. This study aims to evaluate the association between duration of antibiotics and surgical site infection (SSI) in neonatal surgery.
Methods:
A retrospective review regarding antibiotic prophylaxis was performed on <30-day-old surgical patients at a children's hospital from 2014 to 2019. The patients were analyzed based on demographics, presence of SSI, and antibiotic duration. The primary outcome was the development of SSI with ANOVA, chi-square, and recursive partitioning used for statistical analysis.
Results:
19/155 patients developed an SSI (12.26 %). Those with an SSI had a lower weight at surgery (p = 0.03). Additionally, wound classification (p = 0.17) and antibiotic duration >48hrs (p = 0.94) made no statistical difference in SSI rate. The two variables most closely linked to SSI development were gestational age (100 %) and weight at time of procedure (80.76 %).
Conclusions:
Antibiotic prophylaxis >48 h did not decrease the incidence of SSI. Risk factors for SSI development in neonatal surgery were lower gestational age, decreased weight at time of procedure and total length of procedure.
Related Concept Videos
Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
Suctioning the Nasopharyngeal Airway
Equipment Required
Factors Affecting Drug Response: Overview
Parenteral Anesthetics: Overview
Transmission-based Precautions I: Contact, Enteric, and Droplets
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...
Local Anesthetics: Clinical Application as Epidural Anesthesia
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...

