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Updated: Jun 15, 2025
08:25
Identification of Circular RNAs using RNA Sequencing
Published on: November 14, 2019
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Circular RNAs in tumor immunity and immunotherapy
Wenjie Zhang1,2, Chen Xu1, Zhipeng Yang1,2
1Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Molecular Cancer
|August 21, 2024
Summary
Circular RNAs (circRNAs) are key regulators in cancer development and immunity. This review explores how circRNAs influence antitumor immunity and enhance cancer immunotherapy effectiveness, offering new therapeutic targets.
Area of Science:
- Oncology
- Molecular Biology
- Immunology
Background:
- Circular RNAs (circRNAs) are noncoding RNAs with stable, looped structures.
- circRNAs play roles in gene regulation, acting as miRNA sponges and interacting with proteins.
- They are implicated in the development of various malignant tumors.
Purpose of the Study:
- To review current research on circRNAs in antitumor immune regulation.
- To explore the potential of circRNAs in enhancing cancer immunotherapy efficacy.
- To identify novel targets for cancer immunotherapy.
Main Methods:
- Literature review of studies on circRNAs and tumor immunity.
- Analysis of mechanisms by which circRNAs regulate the tumor immune microenvironment.
- Evaluation of circRNAs' role in modulating antitumor immune responses.
Main Results:
- circRNAs are involved in regulating the tumor immune microenvironment and antitumor immunity.
- circRNAs can potentially increase sensitivity to immunotherapy.
- Few studies have comprehensively investigated the link between circRNAs and tumor immunity.
Conclusions:
- circRNAs represent promising targets for improving cancer immunotherapy outcomes.
- Further research is needed to fully elucidate the role of circRNAs in tumor immunity.
- Harnessing circRNAs may expand the patient population benefiting from immunotherapy.
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