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Published on: May 8, 2018
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[Stereotactic high-dose irradiation for intramedullary metastases]
Ya E Goncharov1, I S Zubatkina1,2, P I Ivanov1,3
1Treatment and Diagnostic Center of the Sergei Berezin International Institute of Biological Systems, St. Petersburg, Russia.
Zhurnal Voprosy Neirokhirurgii Imeni N. N. Burdenko
|August 22, 2024
Summary
High-dose stereotactic irradiation effectively controls intramedullary metastases (IMM), improving neurological function. This safe, time-saving treatment offers a viable alternative to surgery or chemotherapy for spinal cord metastases.
Area of Science:
- Neurosurgery
- Radiation Oncology
- Oncology
Context:
- Intramedullary metastases (IMM) are rare and cause severe neurological deficits.
- Optimal management strategies for IMM remain undefined.
- Current treatment options include surgery, chemotherapy, and radiotherapy.
Purpose:
- To evaluate the efficacy of high-dose stereotactic irradiation for IMM.
- To assess local control, neurological status, and survival rates after treatment.
- To determine the safety and feasibility of this treatment modality.
Summary:
- Nineteen patients with 29 IMMs received high-dose irradiation (14.0-35.0 Gy) using Cyber Knife or TrueBeam STx.
- Local control rates were 91% at 6 months and 78% at 12 months.
- Neurological function improved or stabilized in 6 of 8 evaluated patients, with no significant toxicities.
Impact:
- High-dose irradiation demonstrates significant local control and functional improvement in patients with IMM.
- This approach is safe, effective, and time-saving compared to traditional methods.
- Recommends high-dose irradiation as a primary treatment for spinal cord metastases.
