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  11. Apigenin Ameliorates Petrol Vapors-induced Oxidative Stress As Occupational And Environmental Pollutants In Rats: An In Vivo Study

Apigenin ameliorates petrol vapors-induced oxidative stress as occupational and environmental pollutants in rats: An in vivo study

Asghar Ghahri1,2, Mojdeh Saboji3, Hosna Hatami1,4

  • 1Department of Occupational Health and Safety Engineering, School of Health, Alborz University of Medical Sciences, Karaj, Iran.

Archives of Environmental & Occupational Health
|August 22, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Petrol vapor inhalation causes oxidative stress and lowers body weight in rats. Apigenin did not significantly protect against these effects, suggesting further research into natural compounds for mitigating vapor-induced harm.

Area of Science:

  • Environmental Health
  • Toxicology
  • Neuroscience

Background:

  • Occupational and environmental exposure to petrol vapors is a significant concern.
  • Petrol vapors are linked to oxidative stress and potential neurodegenerative diseases.
  • Understanding the toxicological impact of petrol vapors is crucial for public health.

Purpose of the Study:

  • To investigate the protective effects of apigenin (APG) against petrol vapor-induced oxidative stress in a rat model.
  • To evaluate the impact of petrol vapor inhalation on body weight and key oxidative stress markers.
  • To explore the potential of natural compounds like apigenin in mitigating health risks associated with petrol vapor exposure.

Main Methods:

  • A preliminary study involving 24 male Wistar rats randomly assigned to four groups within an inhalation chamber.
Keywords:
AntioxidantsROSapigeninexposure chamber

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  • Exposure of rats to petrol vapors.
  • Monitoring body weight changes and assessing oxidative stress markers, including reactive oxygen species (ROS), oxidized-glutathione (GSSG), reduced-glutathione (GSH), and Malondialdehyde (MDA).
  • Administration of apigenin (APG) to assess its protective efficacy.

    • Main Results:

    • Rats exposed to petrol vapors exhibited significantly lower average body weight compared to control groups.
    • Elevated levels of ROS, GSSG, and MDA were observed in the petrol-exposed group.
    • A decrease in reduced-glutathione (GSH) content was noted in rats exposed to petrol vapors.
    • Apigenin administration did not yield significant improvements in the measured toxicity markers.

    Conclusions:

    • Petrol vapor inhalation induces significant oxidative stress and negatively impacts body weight in rats.
    • Apigenin, in this preliminary study, did not demonstrate significant protective effects against acute petrol vapor-induced toxicity.
    • Further research into natural compounds and chronic exposure scenarios is warranted to explore mitigation strategies for petrol vapor-related health issues, including potential central nervous system (CNS) effects.
    oxidative stress
    petrol vapors