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Updated: Jun 15, 2025

Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions
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Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions

Published on: March 20, 2014

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Halide Salts Alleviate TMSOK Inhibition in Suzuki-Miyaura Cross-Couplings

Yao Shi1, Joshua S Derasp1, Sara M Guzman1

  • 1Department of Chemistry, University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada.

ACS Catalysis
|August 22, 2024
PubMed
Summary

Suzuki-Miyaura cross-coupling reactions are enhanced by halide additives, which accelerate rates and broaden substrate scope. This study reveals halide salts mitigate catalyst inhibition by potassium trimethylsilanolate (TMSOK) and enable challenging protic heterocycle couplings.

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