High expression levels of S1PR3 and PDGFRB indicates unfavorable clinical outcomes in colon adenocarcinoma

Mengsi Yu ¹, Kainan Zhang ^1,2, Song Wang ³

⁰State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Xinjiang Medical University, Department of Clinical Laboratory, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.

Heliyon +

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August 22, 2024

View abstract on PubMed

Summary

Sphingosine kinase 1 (SPHK1) and platelet-derived growth factor receptors (PDGFRs) are upregulated in colon adenocarcinoma (COAD), correlating with poor prognosis and increased metastasis. These findings suggest SPHK1/S1PRs and PDGFRs as potential biomarkers for COAD.

Area Of Science

Oncology
Molecular Biology
Genomics

Background

Sphingosine kinase 1 (SPHK1)/sphingosine 1-phosphate receptors (S1PRs) and platelet-derived growth factor receptors (PDGFRs) are implicated in tumor development.
The specific roles and clinical significance of these pathways in colon adenocarcinoma (COAD) remain largely uncharacterized.

Purpose Of The Study

To investigate the expression patterns of SPHK1/S1PRs and PDGFRs in COAD.
To evaluate the prognostic value of these markers in COAD patients.
To explore potential therapeutic targets and diagnostic biomarkers for COAD.

Main Methods

Utilized The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) databases for expression analysis.
Performed Kaplan-Meier survival, Spearman's correlation, and χ2 tests to assess prognostic and clinical correlations.
Employed Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and Least Absolute Shrinkage and Selection Operator (LASSO) regression for pathway and biomarker identification.

Main Results

SPHK1 and PDGFRB showed significant upregulation in COAD tissues, correlating with shorter overall survival (OS).
High expression of S1PR3 and PDGFRB was associated with advanced N stage and lymph node invasion.
A five-hub gene prognostic model (SFRP2, GPRC5B, RSPO3, FGF14, TCF7L1) demonstrated significant OS prediction and correlated with increased tumor immune cell infiltration.

Conclusions

S1PR3 and PDGFRB may serve as critical biomarkers for predicting lymphatic metastasis and poor prognosis in COAD.
The identified hub genes and their association with immune cell infiltration offer potential therapeutic avenues.
Further research into these pathways could lead to improved COAD management strategies.

Keywords:

Colon adenocarcinoma Lymph invasion PDGFRB Prognosis S1PR3